Drug profile

The FDA adverse-event record for Pegbovigrastim

102 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Pegbovigrastim. See the species affected, top reactions, and outcomes below.

102
adverse-event reports
19.6%
death-coded share
Cattle
most-reported species
30
Lack of efficacy - NOS - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
102
Total Reports
20
Deaths Reported
19.6%
Death Rate

Active Ingredients

Pegbovigrastim

Administration Routes

ParenteralSubcutaneousUnknownIntravenousIntramuscularOral

Species Affected

Cattle 90
Unknown 12

Most Affected Breeds

Holstein-Friesian also known as Holstein 61
Cattle (unknown) 13
Unknown 12
Jersey 6
Mixed (Cattle) 2
Crossbred Bovine/Cattle 2
Guernsey 2
Brown Swiss 1
Holstein - Israeli also known as Israeli Friesian 1
Shorthorn - Milking 1

Most Reported Reactions

Lack of efficacy - NOS 30
Death 14
Metritis 10
Mastitis NOS 9
Displaced abomasum 9
Retained placenta 9
Syringe, Abnormal 8
Ketosis 8
Premature parturition 7
Hypersensitivity reaction 6
Hives (see also 'Skin') 6
Lethargy (see also Central nervous system depression in 'Neurological') 5

Outcome Breakdown

Outcome Unknown
47 (47.5%)
Recovered/Normal
26 (26.3%)
Died
17 (17.2%)
Ongoing
5 (5.1%)
Euthanized
4 (4.0%)

Pegbovigrastim Adverse Event Insights

102 reports name Pegbovigrastim; 20 recorded a death outcome (19.6% of reported events, not a population-level mortality rate). Active ingredient: Pegbovigrastim. Administration routes: Parenteral, Subcutaneous, Unknown, Intravenous.

By species: Cattle (90 reports), Unknown (12 reports). By breed: Holstein-Friesian also known as Holstein (61), Cattle (unknown) (13), Unknown (12).

Leading clinical signs: Lack of efficacy - NOS (30), Death (14), Metritis (10), Mastitis NOS (9). Outcome, 99 coded reports: Outcome Unknown leads at 47.5%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.