Drug profile

The FDA adverse-event record for Oxfendazole

233 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Oxfendazole. See the species affected, top reactions, and outcomes below.

233
adverse-event reports
59.2%
death-coded share
Cattle
most-reported species
127
Death - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
233
Total Reports
138
Deaths Reported
59.2%
Death Rate

Active Ingredients

Oxfendazole

Administration Routes

OralUnknownOtherOropharyngealIntra-AmnioticTopical

Species Affected

Cattle 185
Unknown 25
Dog 15
Sheep 3
Goat 2
Human 2
Bison 1

Most Affected Breeds

Cattle (other) 112
Unknown 28
Crossbred Bovine/Cattle 26
Cattle (unknown) 19
Aberdeen Angus 14
Mixed (Cattle) 5
Holstein-Friesian also known as Holstein 4
Hereford cattle 3
Poodle - Standard 3
Beagle 2

Most Reported Reactions

Death 127
Lack of efficacy - NOS 58
Death by euthanasia 19
Lack of efficacy (bacteria) - NOS 19
CULTURE/TITER DATA ABNORMAL 12
Respiratory signs 11
NT - Abnormal necropsy finding NOS 11
Lack of efficacy (bacteria NOS) 11
Respiratory tract disorder NOS 10
Lack of efficacy (endoparasite) - NOS 10
Lack of efficacy (virus) - NOS 10
Necropsy performed 10

Outcome Breakdown

Died
136 (43.7%)
Outcome Unknown
82 (26.4%)
Ongoing
41 (13.2%)
Recovered/Normal
35 (11.3%)
Euthanized
13 (4.2%)
Recovered with Sequela
4 (1.3%)

Oxfendazole Adverse Event Insights

233 reports name Oxfendazole; 138 recorded a death outcome (59.2% of reported events, not a population-level mortality rate). Active ingredient: Oxfendazole. Administration routes: Oral, Unknown, Other, Oropharyngeal.

By species: Cattle (185 reports), Unknown (25 reports), Dog (15 reports). By breed: Cattle (other) (112), Unknown (28), Crossbred Bovine/Cattle (26).

Leading clinical signs: Death (127), Lack of efficacy - NOS (58), Death by euthanasia (19), Lack of efficacy (bacteria) - NOS (19). Outcome, 311 coded reports: Died leads at 43.7%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.