Drug profile

The FDA adverse-event record for Onsior

162 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Onsior. See the species affected, top reactions, and outcomes below.

162
adverse-event reports
25.3%
death-coded share
Cat
most-reported species
28
Lethargy (see also Central nervous system depression in Neurological) - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
162
Total Reports
41
Deaths Reported
25.3%
Death Rate

Active Ingredients

Onsior

Administration Routes

UnknownOralSubcutaneousIntravenous

Species Affected

Cat 158
Dog 4

Most Affected Breeds

Domestic Shorthair 85
Cat (unknown) 22
Domestic Longhair 13
Cat (other) 10
Siamese 6
Domestic Mediumhair 6
Himalayan 5
Russian 2
Ragdoll 2
Dachshund (unspecified) 2

Most Reported Reactions

Lethargy (see also Central nervous system depression in Neurological) 28
Not eating 24
Death by euthanasia 24
Fever 20
Ataxia 18
Death 17
Weight loss 16
Leucocytosis NOS 13
Not drinking 13
Vomiting 13
Vocalisation 12
Dilated pupils 12

Outcome Breakdown

Ongoing
96 (59.3%)
Euthanized
24 (14.8%)
Died
17 (10.5%)
Outcome Unknown
14 (8.6%)
Recovered/Normal
10 (6.2%)
Recovered with Sequela
1 (0.6%)

Onsior Adverse Event Insights

162 reports name Onsior; 41 recorded a death outcome (25.3% of reported events, not a population-level mortality rate). Active ingredient: Onsior. Administration routes: Unknown, Oral, Subcutaneous, Intravenous.

By species: Cat (158 reports), Dog (4 reports). By breed: Domestic Shorthair (85), Cat (unknown) (22), Domestic Longhair (13).

Leading clinical signs: Lethargy (see also Central nervous system depression in Neurological) (28), Not eating (24), Death by euthanasia (24), Fever (20). Outcome, 162 coded reports: Ongoing leads at 59.3%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.