Drug profile

The FDA adverse-event record for Omeprazole

2,917 FDA reports name Omeprazole, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#76 of 2,679
by report volume (all drugs)
2,917
adverse-event reports
7.9%
death-coded share
Horse
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Omeprazole ranks #76 of 2679 by total reports (2,917) and #647 of 1130 by death-coded share (7.9%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#76
This drug, reports of 2679
#647
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Omeprazole has 2,917 reports now versus 2,749 in that prior snapshot: 168 more (6.1%).

Report change
+168
Death-coded reports
+6
Death-coded share
−0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Omeprazole changes

Signature read: 2,917 reports place Omeprazole in the upper third of FDA AER volume (#76 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
2,917
Total Reports
230
Deaths Reported
7.9%
Death-coded share of reports

Active Ingredients

Omeprazole

Administration Routes

OralUnknownIntravenousTopicalIntramuscularParenteralIntraocularOphthalmic

Species Affected

Horse 1,502
Dog 915
Unknown 421
Human 40
Cat 33
Pig 4
Cattle 1
Mule 1

Most Affected Breeds

Unknown 481
Quarter Horse 332
Horse (unknown) 255
Thoroughbred 252
Warmblood (unspecified) 180
Retriever - Labrador 141
Retriever - Golden 60
Arab 52
Paint 40
Shepherd Dog - German 39

Most Reported Reactions

Lack of efficacy - NOS 810
INEFFECTIVE, GASTRIC ULCER(S) 600
Vomiting 289
Partial lack of efficacy 214
Diarrhoea 209
Death by euthanasia 156
Lethargy (see also Central nervous system depression in 'Neurological') 155
Anorexia 151
Other abnormal test result NOS 140
Lethargy (see also Central nervous system depression in Neurological) 124
Decreased appetite 122
Elevated alanine aminotransferase (ALT) 110

Outcome Breakdown

Ongoing
878 (35.8%)
Outcome Unknown
822 (33.5%)
Recovered/Normal
508 (20.7%)
Euthanized
157 (6.4%)
Died
75 (3.1%)
Recovered with Sequela
13 (0.5%)

Omeprazole: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Omeprazole, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (7.9% here), distinct from the volume row.

Acupuncture 7.9% Hydrolyzed Protein Diet 7.9% Ivermectin(1%)/Clorsulon(10%) Injection 7.9% Dinotefuran, Permethrin, Pyriproxyfen 7.9%

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Omeprazole (#76 of 2,679 by report volume); death-coded 7.9%. PlainBreed drug row · report volume stamp 2,917 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →