Oclacitinib Maleate

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27,759 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
27,759
Total Reports
1,327
Deaths Reported
480.0%
Death Rate

Active Ingredients

Oclacitinib Maleate

Administration Routes

OralUnknownSubcutaneousTopicalOtherOphthalmicParenteralAuricular (Otic)Respiratory (Inhalation)Nasal

Species Affected

Dog 26,292
Unknown 953
Cat 347
Human 148
Horse 11
Monkey 2
Lynx 2
Other Canids 1
Donkey 1
Other Mammals 1

Most Affected Breeds

Retriever - Labrador 2,842
Dog (unknown) 1,852
Terrier - Bull - American Pit 1,331
Retriever - Golden 1,263
Shih Tzu 1,166
Unknown 1,115
Shepherd Dog - German 1,105
Terrier - Yorkshire 892
Crossbred Canine/dog 746
Boxer (German Boxer) 732

Most Reported Reactions

Lack of efficacy - NOS 3,332
Vomiting 3,169
INEFFECTIVE, ATOPY CONTROL 2,700
Diarrhoea 2,134
Lethargy (see also Central nervous system depression in 'Neurological') 2,121
INEFFECTIVE, LOSS OF EFFECT 1,805
Other abnormal test result NOS 1,363
Seizure NOS 1,077
Elevated alanine aminotransferase (ALT) 1,076
Elevated serum alkaline phosphatase (SAP) 1,023
Anorexia 912
Leucopenia NOS 842

Outcome Breakdown

Ongoing
16,190 (60.3%)
Outcome Unknown
5,099 (19.0%)
Recovered/Normal
4,174 (15.6%)
Euthanized
737 (2.7%)
Died
592 (2.2%)
Recovered with Sequela
44 (0.2%)

Data Summary

Metric Value
Total adverse event reports 27,759
Reports involving death 1,327
Case-fatality rate (reported events) 480.0%
Distinct species in reports 10
Distinct breeds in reports 20
Distinct reactions reported 20
Active ingredients on file 1

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER). Counts reflect voluntary reports only.

Oclacitinib Maleate Adverse Event Insights

The FDA Center for Veterinary Medicine database currently holds 27,759 adverse event reports referencing Oclacitinib Maleate, including 1,327 reports in which the animal died — a 480.0% case-fatality figure among reported events only, not a population-level mortality rate. Active ingredient on file: Oclacitinib Maleate. Reported administration routes include Oral, Unknown, Subcutaneous, Topical. These numbers reflect voluntary submissions from pet owners, veterinarians, and manufacturers and therefore under-represent mild events and over-represent severe ones — a pattern the FDA has documented repeatedly for pharmacovigilance datasets.

The species most frequently named in Oclacitinib Maleate reports are Dog (26,292 reports), Unknown (953 reports), Cat (347 reports), with Dog accounting for the largest share. Within those species, Retriever - Labrador (2,842), Dog (unknown) (1,852), Terrier - Bull - American Pit (1,331) appear most often — though breed popularity and ownership density shape these counts as much as any drug-specific sensitivity. This distribution matters because the same active ingredient can behave very differently across body sizes, ages, and species physiology.

The most commonly reported clinical signs associated with Oclacitinib Maleate are Lack of efficacy - NOS (3,332), Vomiting (3,169), INEFFECTIVE, ATOPY CONTROL (2,700), Diarrhoea (2,134). Of the 26,836 reports with a coded outcome, Ongoing is the leading category at 60.3%. Because FDA adverse event data describes correlation rather than causation, these figures are best used to frame informed questions with a veterinarian and to compare reporting patterns across related products — not as a standalone safety verdict on Oclacitinib Maleate.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial