Drug profile

The FDA adverse-event record for Nutritional Supplement

81 FDA reports name Nutritional Supplement, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#869 of 2,679
by report volume (all drugs)
81
adverse-event reports
17.3%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Nutritional Supplement ranks #866 of 2679 by total reports (81) and #291 of 1130 by death-coded share (17.3%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#866
This drug, reports of 2679
#291
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Nutritional Supplement has 81 reports now versus 80 in that prior snapshot: 1 more (1.3%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Nutritional Supplement changes

Signature read: death-coded report count at 14 is the most distinctive stamp on Nutritional Supplement's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
81
Total Reports
14
Deaths Reported
17.3%
Death-coded share of reports

Active Ingredients

Nutritional Supplement

Administration Routes

OralUnknown

Species Affected

Dog 70
Cat 9
Horse 2

Most Affected Breeds

Retriever - Labrador 9
Domestic Shorthair 8
Retriever - Golden 8
Crossbred Canine/dog 5
Dog (unknown) 5
Collie - Border 4
Shepherd Dog - German 3
Sheepdog - Shetland 3
Corgi - Welsh Pembroke 2
Corgi (unspecified) 2

Most Reported Reactions

Vomiting 17
Lethargy (see also Central nervous system depression in 'Neurological') 15
Diarrhoea 14
Anorexia 10
Not eating 10
Elevated liver enzymes 9
Death 9
Other abnormal test result NOS 8
Weight loss 8
Emesis 7
Elevated creatinine 7
Seizure NOS 6

Outcome Breakdown

Outcome Unknown
29 (35.8%)
Ongoing
25 (30.9%)
Recovered/Normal
12 (14.8%)
Died
9 (11.1%)
Euthanized
5 (6.2%)
Recovered with Sequela
1 (1.2%)

Nutritional Supplement: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Nutritional Supplement, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (17.3% here), distinct from the volume row.

What to do with this drug

  • Compare Nutritional Supplement's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Nutritional Supplement (#869 of 2,679 by report volume); death-coded 17.3%. PlainBreed drug row · death-coded report count stamp 14 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →