Drug profile

The FDA adverse-event record for Nph Insulin

44 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Nph Insulin. See the species affected, top reactions, and outcomes below.

44
adverse-event reports
9.1%
death-coded share
Dog
most-reported species
19
Hyperglycaemia - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
44
Total Reports
4
Deaths Reported
9.1%
Death Rate

Active Ingredients

Nph Insulin

Administration Routes

SubcutaneousUnknownParenteral

Species Affected

Dog 43
Cat 1

Most Affected Breeds

Terrier - Jack Russell 4
Pinscher - Miniature 4
Shih Tzu 3
Schnauzer - Miniature 3
Chihuahua 3
Maltese 3
Terrier - Boston 3
Dachshund - Standard Smooth-haired 2
Schnauzer (unspecified) 2
Shepherd (unspecified) 2

Most Reported Reactions

Hyperglycaemia 19
Weight loss 14
Hyperkalaemia 13
Other abnormal test result NOS 8
Hyponatremia 8
Lethargy (see also Central nervous system depression in 'Neurological') 8
Vomiting 8
Low sodium-potassium ratio (Na:K ratio) 7
Hypoglycaemia 7
Elevated alanine aminotransferase (ALT) 7
Elevated serum alkaline phosphatase (SAP) 7
Elevated blood urea nitrogen (BUN) 5

Outcome Breakdown

Outcome Unknown
25 (56.8%)
Ongoing
11 (25.0%)
Recovered/Normal
4 (9.1%)
Euthanized
2 (4.5%)
Died
2 (4.5%)

Nph Insulin Adverse Event Insights

44 reports name Nph Insulin; 4 recorded a death outcome (9.1% of reported events, not a population-level mortality rate). Active ingredient: Nph Insulin. Administration routes: Subcutaneous, Unknown, Parenteral.

By species: Dog (43 reports), Cat (1 reports). By breed: Terrier - Jack Russell (4), Pinscher - Miniature (4), Shih Tzu (3).

Leading clinical signs: Hyperglycaemia (19), Weight loss (14), Hyperkalaemia (13), Other abnormal test result NOS (8). Outcome, 44 coded reports: Outcome Unknown leads at 56.8%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.