Drug profile

The FDA adverse-event record for [No Api/Abi]

32 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference [No Api/Abi]. See the species affected, top reactions, and outcomes below.

32
adverse-event reports
15.6%
death-coded share
Dog
most-reported species
8
Lack of efficacy (endoparasite) - heartworm - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
32
Total Reports
5
Deaths Reported
15.6%
Death Rate

Active Ingredients

[No Api/Abi]

Administration Routes

OralUnknown

Species Affected

Dog 19
Cat 12
Unknown 1

Most Affected Breeds

Domestic Shorthair 9
Retriever - Labrador 3
Poodle (unspecified) 2
Retriever - Golden 2
Chihuahua 2
Pug 1
Unknown 1
Poodle - Toy 1
Hound - Basset 1
Shepherd Dog - German 1

Most Reported Reactions

Lack of efficacy (endoparasite) - heartworm 8
Weight loss 7
Anaemia NOS 6
Anorexia 4
Other abnormal test result NOS 4
Lethargy (see also Central nervous system depression in 'Neurological') 3
Death 3
Elevated symmetrical dimethylarginine (SDMA) 3
Abnormal cytology 3
Vomiting 3
Bacterial skin infection NOS 3
Seizure NOS 2

Outcome Breakdown

Ongoing
20 (64.5%)
Outcome Unknown
4 (12.9%)
Died
3 (9.7%)
Euthanized
2 (6.5%)
Recovered/Normal
2 (6.5%)

[No Api/Abi] Adverse Event Insights

32 reports name [No Api/Abi]; 5 recorded a death outcome (15.6% of reported events, not a population-level mortality rate). Active ingredient: [No Api/Abi]. Administration routes: Oral, Unknown.

By species: Dog (19 reports), Cat (12 reports), Unknown (1 reports). By breed: Domestic Shorthair (9), Retriever - Labrador (3), Poodle (unspecified) (2).

Leading clinical signs: Lack of efficacy (endoparasite) - heartworm (8), Weight loss (7), Anaemia NOS (6), Anorexia (4). Outcome, 31 coded reports: Ongoing leads at 64.5%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.