Drug profile

The FDA adverse-event record for Neomycin Sulfate, Usp + Nystatin, Usp + Thiostrepton, [Usp] + Triamcinolone Acetonide, Usp

152 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Neomycin Sulfate, Usp + Nystatin, Usp + Thiostrepton, [Usp] + Triamcinolone Acetonide, Usp. See the species affected, top reactions, and outcomes below.

152
adverse-event reports
1.3%
death-coded share
Dog
most-reported species
61
Deafness - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
152
Total Reports
2
Deaths Reported
1.3%
Death Rate

Active Ingredients

Neomycin Sulfate, UspNystatin, UspThiostrepton, [Usp]Triamcinolone Acetonide, Usp

Administration Routes

Auricular (Otic)UnknownTopicalTransdermal

Species Affected

Dog 136
Cat 10
Unknown 5
Other Birds 1

Most Affected Breeds

Unknown 22
Terrier - Yorkshire 11
Retriever - Labrador 9
Shih Tzu 8
Bichon Frise 6
Shepherd Dog - German 5
Chihuahua 5
Maltese 4
Domestic Shorthair 4
Mixed (Dog) 4

Most Reported Reactions

Deafness 61
Temporary deafness 49
PR-EAR(S), LESION(S) 41
Vomiting 6
Loss of hearing 4
Unclassifiable adverse event 4
Indigestion 4
Tubes, Leaking 3
Caps, Abnormal 2
Partial deafness 2
Death 2
Hearing decreased 2

Outcome Breakdown

Ongoing
58 (39.7%)
Recovered/Normal
47 (32.2%)
Outcome Unknown
37 (25.3%)
Recovered with Sequela
2 (1.4%)
Died
2 (1.4%)

Neomycin Sulfate, Usp + Nystatin, Usp + Thiostrepton, [Usp] + Triamcinolone Acetonide, Usp Adverse Event Insights

152 reports name Neomycin Sulfate, Usp + Nystatin, Usp + Thiostrepton, [Usp] + Triamcinolone Acetonide, Usp; 2 recorded a death outcome (1.3% of reported events, not a population-level mortality rate). Active ingredients: Neomycin Sulfate, Usp, Nystatin, Usp, Thiostrepton, [Usp], Triamcinolone Acetonide, Usp. Administration routes: Auricular (Otic), Unknown, Topical, Transdermal.

By species: Dog (136 reports), Cat (10 reports), Unknown (5 reports). By breed: Unknown (22), Terrier - Yorkshire (11), Retriever - Labrador (9).

Leading clinical signs: Deafness (61), Temporary deafness (49), PR-EAR(S), LESION(S) (41), Vomiting (6). Outcome, 146 coded reports: Ongoing leads at 39.7%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.