Drug profile

The FDA adverse-event record for Neomycin Sulfate Equivalent To Neomycin Base + Nystatin + Thiostrepton

62 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Neomycin Sulfate Equivalent To Neomycin Base + Nystatin + Thiostrepton. See the species affected, top reactions, and outcomes below.

62
adverse-event reports
6.5%
death-coded share
Dog
most-reported species
34
Deafness - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
62
Total Reports
4
Deaths Reported
6.5%
Death Rate

Active Ingredients

Neomycin Sulfate Equivalent To Neomycin BaseNystatinThiostrepton

Administration Routes

UnknownAuricular (Otic)TopicalOphthalmic

Species Affected

Dog 50
Cat 12

Most Affected Breeds

Domestic Shorthair 7
Unknown 4
Bulldog - French 3
Retriever - Golden 3
Boxer (German Boxer) 3
Dog (unknown) 3
Maltese 3
Chihuahua 3
Poodle - Toy 2
Terrier (unspecified) 2

Most Reported Reactions

Deafness 34
Emesis 8
Impaired hearing 4
Ataxia 4
Lack of efficacy - NOS 3
Ear canal disorder 3
Incorrect route of drug administration 3
Accidental exposure 3
Partial deafness 3
Anorexia 3
Behavioural disorder NOS 3
Otorrhoea 2

Outcome Breakdown

Outcome Unknown
41 (66.1%)
Recovered/Normal
7 (11.3%)
Recovered with Sequela
6 (9.7%)
Ongoing
4 (6.5%)
Died
3 (4.8%)
Euthanized
1 (1.6%)

Neomycin Sulfate Equivalent To Neomycin Base + Nystatin + Thiostrepton Adverse Event Insights

62 reports name Neomycin Sulfate Equivalent To Neomycin Base + Nystatin + Thiostrepton; 4 recorded a death outcome (6.5% of reported events, not a population-level mortality rate). Active ingredients: Neomycin Sulfate Equivalent To Neomycin Base, Nystatin, Thiostrepton. Administration routes: Unknown, Auricular (Otic), Topical, Ophthalmic.

By species: Dog (50 reports), Cat (12 reports). By breed: Domestic Shorthair (7), Unknown (4), Bulldog - French (3).

Leading clinical signs: Deafness (34), Emesis (8), Impaired hearing (4), Ataxia (4). Outcome, 62 coded reports: Outcome Unknown leads at 66.1%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.