Drug profile

The FDA adverse-event record for Neomycin + Nystatin + Thiostrepton + Triamcinolone Acetonide

75 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Neomycin + Nystatin + Thiostrepton + Triamcinolone Acetonide. See the species affected, top reactions, and outcomes below.

75
adverse-event reports
2.7%
death-coded share
Dog
most-reported species
24
Deafness - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
75
Total Reports
2
Deaths Reported
2.7%
Death Rate

Active Ingredients

NeomycinNystatinThiostreptonTriamcinolone Acetonide

Administration Routes

Auricular (Otic)TopicalUnknownOralOphthalmic

Species Affected

Dog 63
Cat 8
Unknown 4

Most Affected Breeds

Chihuahua 8
Domestic Shorthair 7
Unknown 4
Dog (unknown) 3
Retriever - Golden 3
Retriever - Labrador 3
Bulldog - French 3
Pug 3
Shih Tzu 3
Terrier - Yorkshire 3

Most Reported Reactions

Deafness 24
Partial deafness 6
Lack of efficacy - NOS 5
Vomiting 5
Loss of hearing 5
Accidental exposure 5
Ear discharge 5
Lethargy (see also Central nervous system depression in Neurological) 5
Diarrhoea 4
Not eating 4
Polydipsia 3
Temporary deafness 3

Outcome Breakdown

Outcome Unknown
24 (33.8%)
Recovered with Sequela
23 (32.4%)
Recovered/Normal
20 (28.2%)
Ongoing
2 (2.8%)
Euthanized
2 (2.8%)

Neomycin + Nystatin + Thiostrepton + Triamcinolone Acetonide Adverse Event Insights

75 reports name Neomycin + Nystatin + Thiostrepton + Triamcinolone Acetonide; 2 recorded a death outcome (2.7% of reported events, not a population-level mortality rate). Active ingredients: Neomycin, Nystatin, Thiostrepton, Triamcinolone Acetonide. Administration routes: Auricular (Otic), Topical, Unknown, Oral.

By species: Dog (63 reports), Cat (8 reports), Unknown (4 reports). By breed: Chihuahua (8), Domestic Shorthair (7), Unknown (4).

Leading clinical signs: Deafness (24), Partial deafness (6), Lack of efficacy - NOS (5), Vomiting (5). Outcome, 71 coded reports: Outcome Unknown leads at 33.8%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.