Drug profile

The FDA adverse-event record for Milbemycin Oxime,Praziquantel Micronized

137 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Milbemycin Oxime,Praziquantel Micronized. See the species affected, top reactions, and outcomes below.

137
adverse-event reports
2.2%
death-coded share
Dog
most-reported species
46
Lack of efficacy (endoparasite) - heartworm - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
137
Total Reports
3
Deaths Reported
2.2%
Death Rate

Active Ingredients

Milbemycin Oxime,Praziquantel Micronized

Administration Routes

OralUnknownTopical

Species Affected

Dog 136
Unknown 1

Most Affected Breeds

Retriever - Labrador 14
Crossbred Canine/dog 10
Retriever - Golden 10
Shepherd Dog - Australian 8
Shepherd Dog - German 7
Dog (unknown) 7
Beagle 7
Terrier - Bull - American Pit 6
Dachshund (unspecified) 5
Collie - Border 5

Most Reported Reactions

Lack of efficacy (endoparasite) - heartworm 46
Vomiting 19
Lack of efficacy (endoparasite) - hookworm 14
Diarrhoea 14
Lack of efficacy (endoparasite) - tapeworm 12
Lack of efficacy (endoparasite) - roundworm NOS 8
Lethargy (see also Central nervous system depression in Neurological) 7
Elevated alanine aminotransferase (ALT) 6
Collapse NOS (see also Cardio-vascular and Neurological disorders) 5
Not eating 5
Lack of efficacy (bacteria) - Borrelia 4
Seizure NOS 4

Outcome Breakdown

Outcome Unknown
85 (62.5%)
Recovered/Normal
25 (18.4%)
Ongoing
23 (16.9%)
Euthanized
3 (2.2%)

Milbemycin Oxime,Praziquantel Micronized Adverse Event Insights

137 reports name Milbemycin Oxime,Praziquantel Micronized; 3 recorded a death outcome (2.2% of reported events, not a population-level mortality rate). Active ingredient: Milbemycin Oxime,Praziquantel Micronized. Administration routes: Oral, Unknown, Topical.

By species: Dog (136 reports), Unknown (1 reports). By breed: Retriever - Labrador (14), Crossbred Canine/dog (10), Retriever - Golden (10).

Leading clinical signs: Lack of efficacy (endoparasite) - heartworm (46), Vomiting (19), Lack of efficacy (endoparasite) - hookworm (14), Diarrhoea (14). Outcome, 136 coded reports: Outcome Unknown leads at 62.5%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.