Milbemycin Oxime, Praziquantel
1,195 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,195
Total Reports
44
Deaths Reported
370.0%
Death Rate
Active Ingredients
Milbemycin Oxime, Praziquantel
Administration Routes
OralUnknownTopicalOther
Species Affected
Dog 1,178
Unknown 15
Human 1
Cat 1
Most Affected Breeds
Retriever - Labrador 164
Crossbred Canine/dog 83
Retriever - Golden 67
Shepherd Dog - German 65
Dog (unknown) 54
Shepherd Dog - Australian 45
Beagle 37
Chihuahua 36
Pit Bull 34
Terrier - Yorkshire 26
Most Reported Reactions
Lack of efficacy (endoparasite) - heartworm 314
Vomiting 203
Diarrhoea 88
Lack of efficacy (endoparasite) - hookworm 88
Lethargy (see also Central nervous system depression in Neurological) 87
Lack of efficacy (endoparasite) - tapeworm 63
Other abnormal test result NOS 54
Lack of efficacy (endoparasite) - NOS 50
Seizure NOS 47
Lack of efficacy (endoparasite) - roundworm NOS 47
Not eating 43
Loose stool 39
Outcome Breakdown
Outcome Unknown
631 (53.5%)
Recovered/Normal
258 (21.9%)
Ongoing
244 (20.7%)
Died
24 (2.0%)
Euthanized
20 (1.7%)
Recovered with Sequela
3 (0.3%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.