Milbemycin Oxime + Praziquantel
34,806 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
34,806
Total Reports
882
Deaths Reported
250.0%
Death Rate
Active Ingredients
Milbemycin OximeMilbemycin Oxime + PraziquantelPraziquantel
Administration Routes
OralUnknownTopicalOtherCutaneousRectalSubcutaneousIntraocularOphthalmicIntracardiac
Species Affected
Dog 32,702
Unknown 2,072
Cat 15
Human 14
Other 2
Other Canids 1
Most Affected Breeds
Retriever - Labrador 5,387
Unknown 2,116
Retriever - Golden 1,961
Shepherd Dog - German 1,894
Crossbred Canine/dog 1,694
Dog (unknown) 1,407
Pit Bull 1,187
Shepherd Dog - Australian 1,075
Beagle 943
Chihuahua 734
Most Reported Reactions
Lack of efficacy (endoparasite) - heartworm 9,737
Vomiting 6,439
Diarrhoea 2,410
INEFFECTIVE, HOOKS 2,404
Lack of efficacy (endoparasite) - hookworm 2,336
Lethargy (see also Central nervous system depression in 'Neurological') 1,799
Other abnormal test result NOS 1,741
UNPALATABLE 1,727
Lack of efficacy (roundworm) 1,286
Lack of efficacy (endoparasite) - roundworm NOS 1,141
Seizure NOS 796
Not eating 731
Outcome Breakdown
Outcome Unknown
21,114 (64.5%)
Recovered/Normal
6,982 (21.3%)
Ongoing
3,695 (11.3%)
Died
556 (1.7%)
Euthanized
327 (1.0%)
Recovered with Sequela
69 (0.2%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.