Milbemycin Oxime + Lufenuron + Praziquantel
170 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
170
Total Reports
4
Deaths Reported
240.0%
Death Rate
Active Ingredients
Milbemycin Oxime + Lufenuron + Praziquantel
Administration Routes
OralUnknownOther
Species Affected
Dog 169
Unknown 1
Most Affected Breeds
Retriever - Labrador 32
Crossbred Canine/dog 14
Chihuahua 9
Shepherd Dog - German 8
Pit Bull 6
Shepherd Dog - Australian 6
Boxer (German Boxer) 6
Retriever - Golden 5
Corgi (unspecified) 4
Beagle 4
Most Reported Reactions
Lack of efficacy (endoparasite) - heartworm 57
Vomiting 35
Other abnormal test result NOS 19
Lethargy (see also Central nervous system depression in 'Neurological') 17
Diarrhoea 12
Behavioural disorder NOS 9
Emesis 8
Lack of efficacy - NOS 6
INEFFECTIVE, HEARTWORM LARVAE 6
Seizure NOS 6
Decreased appetite 6
Lack of efficacy (endoparasite) - tapeworm 6
Outcome Breakdown
Outcome Unknown
93 (55.0%)
Recovered/Normal
39 (23.1%)
Ongoing
29 (17.2%)
Recovered with Sequela
4 (2.4%)
Died
2 (1.2%)
Euthanized
2 (1.2%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.