Milbemycin Oxime + Lufenuron
1,093 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,093
Total Reports
42
Deaths Reported
380.0%
Death Rate
Active Ingredients
Milbemycin Oxime + Lufenuron
Administration Routes
OralUnknownIntraocularTopicalOther
Species Affected
Dog 1,090
Unknown 3
Most Affected Breeds
Retriever - Labrador 153
Retriever - Golden 49
Shepherd Dog - German 48
Terrier - Yorkshire 48
Crossbred Canine/dog 46
Chihuahua 37
Maltese 33
Beagle 33
Shepherd Dog - Australian 26
Pit Bull 26
Most Reported Reactions
Lack of efficacy (endoparasite) - heartworm 211
Emesis 178
Vomiting 160
Lethargy (see also Central nervous system depression in 'Neurological') 112
Diarrhoea 78
INEFFECTIVE, HEARTWORM LARVAE 77
Lack of efficacy (ectoparasite) - flea 70
Lack of efficacy - NOS 58
Other abnormal test result NOS 48
Seizure NOS 44
Weight loss 38
Behavioural disorder NOS 37
Outcome Breakdown
Outcome Unknown
504 (46.2%)
Recovered/Normal
374 (34.3%)
Ongoing
124 (11.4%)
Recovered with Sequela
46 (4.2%)
Died
24 (2.2%)
Euthanized
18 (1.7%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.