Drug profile

The FDA adverse-event record for Milbemycin Oxime + Lufenuron

1,093 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Milbemycin Oxime + Lufenuron. See the species affected, top reactions, and outcomes below.

1,093
adverse-event reports
3.8%
death-coded share
Dog
most-reported species
211
Lack of efficacy (endoparasite) - heartworm - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,093
Total Reports
42
Deaths Reported
3.8%
Death Rate

Active Ingredients

Milbemycin Oxime + Lufenuron

Administration Routes

OralUnknownIntraocularTopicalOther

Species Affected

Dog 1,090
Unknown 3

Most Affected Breeds

Retriever - Labrador 153
Retriever - Golden 49
Shepherd Dog - German 48
Terrier - Yorkshire 48
Crossbred Canine/dog 46
Chihuahua 37
Maltese 33
Beagle 33
Shepherd Dog - Australian 26
Pit Bull 26

Most Reported Reactions

Lack of efficacy (endoparasite) - heartworm 211
Emesis 178
Vomiting 160
Lethargy (see also Central nervous system depression in 'Neurological') 112
Diarrhoea 78
INEFFECTIVE, HEARTWORM LARVAE 77
Lack of efficacy (ectoparasite) - flea 70
Lack of efficacy - NOS 58
Other abnormal test result NOS 48
Seizure NOS 44
Weight loss 38
Behavioural disorder NOS 37

Outcome Breakdown

Outcome Unknown
504 (46.2%)
Recovered/Normal
374 (34.3%)
Ongoing
124 (11.4%)
Recovered with Sequela
46 (4.2%)
Died
24 (2.2%)
Euthanized
18 (1.7%)

Milbemycin Oxime + Lufenuron Adverse Event Insights

1,093 reports name Milbemycin Oxime + Lufenuron; 42 recorded a death outcome (3.8% of reported events, not a population-level mortality rate). Active ingredient: Milbemycin Oxime + Lufenuron. Administration routes: Oral, Unknown, Intraocular, Topical.

By species: Dog (1,090 reports), Unknown (3 reports). By breed: Retriever - Labrador (153), Retriever - Golden (49), Shepherd Dog - German (48).

Leading clinical signs: Lack of efficacy (endoparasite) - heartworm (211), Emesis (178), Vomiting (160), Lethargy (see also Central nervous system depression in 'Neurological') (112). Outcome, 1,090 coded reports: Outcome Unknown leads at 46.2%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.