Milbemycin Oxime, Lufenuron

6,743 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.

6,743

Total Reports

Deaths Reported

90.0%

Death Rate

Active Ingredients

Milbemycin Oxime, Lufenuron

Administration Routes

OralUnknownTopicalIntrauterine

Species Affected

Dog 6,527

Unknown 196

Cat 10

Human 9

Goat 1

Most Affected Breeds

Crossbred Canine/dog 942

Retriever - Labrador 903

Dog (unknown) 355

Shepherd Dog - German 329

Retriever - Golden 322

Beagle 209

Unknown 206

Terrier - Yorkshire 150

Chihuahua 142

Boxer (German Boxer) 134

Most Reported Reactions

INEFFECTIVE, HEARTWORM LARVAE 1,493

Lack of efficacy (endoparasite) - hookworm 1,406

Vomiting 1,011

INEFFECTIVE, ASCARIDS NOS 838

Diarrhoea 583

Lethargy (see also Central nervous system depression in 'Neurological') 428

Lack of efficacy (endoparasite) - whipworm 424

Lack of efficacy - NOS 348

Lack of efficacy (ectoparasite) - flea 300

INEFFECTIVE, HOOKS 220

Underdose 184

Overdose 181

Outcome Breakdown

Outcome Unknown

4,561 (69.6%)

Recovered/Normal

1,798 (27.4%)

Ongoing

100 (1.5%)

Died

32 (0.5%)

Euthanized

31 (0.5%)

Recovered with Sequela

29 (0.4%)

Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.