Drug profile

The FDA adverse-event record for Milbemycin Oxime And Lufenuron

30 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Milbemycin Oxime And Lufenuron. Species, reactions, and outcomes follow.

#1453 of 2,679
by report volume (all drugs)
30
adverse-event reports
6.7%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Milbemycin Oxime And Lufenuron ranks #1440 of 2679 by total reports (30). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1440
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Milbemycin Oxime And Lufenuron has 30 reports now versus 30 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Milbemycin Oxime And Lufenuron changes

Signature read: death-coded report count at 2 is the most distinctive stamp on Milbemycin Oxime And Lufenuron's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
30
Total Reports
2
Deaths Reported
6.7%
Death-coded share of reports

Active Ingredients

Milbemycin Oxime And Lufenuron

Administration Routes

OralUnknown

Species Affected

Dog 30

Most Affected Breeds

Retriever - Labrador 5
Shepherd Dog - Australian 3
Terrier - Boston 2
Greyhound 1
Mountain Dog - Bernese 1
Pointing Dog - German Short-haired 1
Beagle 1
Terrier (unspecified) 1
Poodle - Miniature 1
Weimaraner 1

Most Reported Reactions

Vomiting 8
Elevated alanine aminotransferase (ALT) 4
Not eating 4
Facial swelling (see also 'Skin') 3
Elevated total bilirubin 3
Elevated bile acids 3
Elevated serum alkaline phosphatase (ALP) 3
Liver failure 3
Phlebitis 2
Pain NOS 2
Death by euthanasia 2
Decreased appetite 2

Outcome Breakdown

Recovered/Normal
12 (40.0%)
Outcome Unknown
9 (30.0%)
Ongoing
7 (23.3%)
Euthanized
2 (6.7%)

Milbemycin Oxime And Lufenuron Adverse Event Insights

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Milbemycin Oxime And Lufenuron (#1453 of 2,679 by report volume); death-coded 6.7%. PlainBreed drug row · death-coded report count stamp 2 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →