Milbemycin Oxime

9,719 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.

9,719

Total Reports

378

Deaths Reported

390.0%

Death Rate

Active Ingredients

Milbemycin Oxime

Administration Routes

OralUnknownAuricular (Otic)TopicalOtherIntraocularIntrauterineRespiratory (Inhalation)CutaneousUrethral

Species Affected

Dog 8,952

Unknown 542

Cat 199

Human 21

Other Canids 1

Primate 1

Rabbit 1

Cockatiel 1

Ferret 1

Most Affected Breeds

Retriever - Labrador 1,524

Unknown 574

Crossbred Canine/dog 561

Shepherd Dog - German 464

Retriever - Golden 418

Dog (unknown) 335

Beagle 294

Shepherd Dog - Australian 227

Chihuahua 216

Pit Bull 210

Most Reported Reactions

INEFFECTIVE, HEARTWORM LARVAE 2,087

Vomiting 1,238

Lack of efficacy (endoparasite) - heartworm 1,181

Lethargy (see also Central nervous system depression in 'Neurological') 653

Diarrhoea 634

Lack of efficacy - NOS 515

Emesis 485

Lack of efficacy (endoparasite) - hookworm 484

Other abnormal test result NOS 329

INEFFECTIVE, ASCARIDS NOS 324

Seizure NOS 321

INEFFECTIVE, HOOKS 273

Outcome Breakdown

Outcome Unknown

3,187 (34.8%)

Ongoing

3,099 (33.8%)

Recovered/Normal

2,388 (26.1%)

Died

232 (2.5%)

Euthanized

146 (1.6%)

Recovered with Sequela

113 (1.2%)

Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.