Milbemycin, Lufenuron
2,328 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
2,328
Total Reports
35
Deaths Reported
150.0%
Death Rate
Active Ingredients
Milbemycin, Lufenuron
Administration Routes
OralUnknownTopicalOphthalmic
Species Affected
Dog 2,207
Unknown 108
Human 9
Cat 3
Other 1
Most Affected Breeds
Crossbred Canine/dog 537
Retriever - Labrador 283
Unknown 118
Retriever - Golden 88
Shepherd Dog - German 81
Terrier - Yorkshire 60
Chihuahua 59
Dog (unknown) 56
Shih Tzu 55
Beagle 55
Most Reported Reactions
INEFFECTIVE, HEARTWORM LARVAE 757
Vomiting 446
INEFFECTIVE, ASCARIDS NOS 233
Lack of efficacy (endoparasite) - hookworm 227
Diarrhoea 212
Depression 202
Lack of efficacy (endoparasite) - whipworm 124
Pruritus 116
Anorexia 115
Convulsion 73
Underfilling, Package 55
Ataxia 42
Outcome Breakdown
Died
35 (87.5%)
Ongoing
5 (12.5%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.