Milbemcyin Oxime, Lufenuron, Praziquantel
3,685 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
3,685
Total Reports
41
Deaths Reported
110.0%
Death Rate
Active Ingredients
Milbemcyin Oxime, Lufenuron, Praziquantel
Administration Routes
OralUnknownOtherTopical
Species Affected
Dog 3,486
Unknown 193
Human 3
Cat 2
Other Canids 1
Most Affected Breeds
Retriever - Labrador 481
Crossbred Canine/dog 418
Unknown 198
Shepherd Dog - German 164
Retriever - Golden 151
Dog (unknown) 124
Chihuahua 107
Beagle 101
Terrier - Yorkshire 89
Collie - Border 87
Most Reported Reactions
INEFFECTIVE, HEARTWORM LARVAE 617
Vomiting 589
Lack of efficacy (endoparasite) - hookworm 549
Diarrhoea 322
INEFFECTIVE, ASCARIDS NOS 301
Lethargy (see also Central nervous system depression in 'Neurological') 250
Lack of efficacy (endoparasite) - tapeworm 225
Lack of efficacy - NOS 215
Lack of efficacy (endoparasite) - whipworm 157
Emesis 131
Lack of efficacy (ectoparasite) - flea 128
INEFFECTIVE, HOOKS 114
Outcome Breakdown
Outcome Unknown
2,065 (59.1%)
Recovered/Normal
1,205 (34.5%)
Ongoing
170 (4.9%)
Died
26 (0.7%)
Euthanized
15 (0.4%)
Recovered with Sequela
14 (0.4%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.