Drug profile

The FDA adverse-event record for Miconazole Nitrate + Chlorhexidine Gluconate + Trizedta

31 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Miconazole Nitrate + Chlorhexidine Gluconate + Trizedta. Species, reactions, and outcomes follow.

#1432 of 2,679
by report volume (all drugs)
31
adverse-event reports
6.5%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Miconazole Nitrate + Chlorhexidine Gluconate + Trizedta ranks #1412 of 2679 by total reports (31). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1412
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Miconazole Nitrate + Chlorhexidine Gluconate + Trizedta has 31 reports now versus 28 in that prior snapshot: 3 more (10.7%).

Report change
+3
Death-coded reports
+0
Death-coded share
−0.7 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Miconazole Nitrate + Chlorhexidine Gluconate + Trizedta changes

Signature read: death-coded share at 6.5% is the most distinctive stamp on Miconazole Nitrate + Chlorhexidine Gluconate + Trizedta's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
31
Total Reports
2
Deaths Reported
6.5%
Death-coded share of reports

Active Ingredients

Miconazole Nitrate + Chlorhexidine Gluconate + Trizedta

Administration Routes

TopicalUnknownAuricular (Otic)Cutaneous

Species Affected

Dog 26
Cat 5

Most Affected Breeds

Retriever - Labrador 6
Domestic Shorthair 4
Retriever - Golden 3
Sheepdog - Shetland 2
Collie - Border 2
Pit Bull 2
Shepherd Dog - Belgian (unspecified) 2
Shepherd Dog - German 1
Spaniel - Cocker American 1
Dog (unknown) 1

Most Reported Reactions

Lethargy (see also Central nervous system depression in Neurological) 5
Lack of efficacy - NOS 4
Alopecia NOS 4
Neutropenia 4
Decreased haematocrit 4
Vomiting 3
Pruritus 3
Exudative skin condition 3
Erythema (for urticaria see Immune SOC) 3
Comedo/blackhead 3
Ear canal erythema 3
Hyperpigmentation 3

Outcome Breakdown

Ongoing
13 (41.9%)
Outcome Unknown
9 (29.0%)
Recovered/Normal
7 (22.6%)
Euthanized
2 (6.5%)

Miconazole Nitrate + Chlorhexidine Gluconate + Trizedta Adverse Event Insights

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Miconazole Nitrate + Chlorhexidine Gluconate + Trizedta (#1432 of 2,679 by report volume); death-coded 6.5%. PlainBreed drug row · death-coded share stamp 6.5% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →