Drug profile

The FDA adverse-event record for Miconazole Nitrate + Chlorhexidine Gluconate + Trizedta

20 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Miconazole Nitrate + Chlorhexidine Gluconate + Trizedta. See the species affected, top reactions, and outcomes below.

20
adverse-event reports
10.0%
death-coded share
Dog
most-reported species
5
Lethargy (see also Central nervous system depression in Neurological) - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
20
Total Reports
2
Deaths Reported
10.0%
Death Rate

Active Ingredients

Miconazole Nitrate + Chlorhexidine Gluconate + Trizedta

Administration Routes

TopicalUnknownCutaneousAuricular (Otic)

Species Affected

Dog 16
Cat 4

Most Affected Breeds

Domestic Shorthair 4
Retriever - Golden 2
Sheepdog - Shetland 2
Collie - Border 2
Retriever - Labrador 2
Shepherd Dog - German 1
Spaniel - Cocker American 1
Dog (unknown) 1
Cattle Dog (unspecified) 1
Boxer (German Boxer) 1

Most Reported Reactions

Lethargy (see also Central nervous system depression in Neurological) 5
Vomiting 3
Neutropenia 3
Lack of efficacy - NOS 2
Diarrhoea 2
Liver disorder NOS 2
Arthritis 2
Ringworm 2
Lack of efficacy (flea) 2
Decreased appetite 2
Hypersalivation 2
Elevated cholesterol (total) 2

Outcome Breakdown

Ongoing
8 (40.0%)
Outcome Unknown
6 (30.0%)
Recovered/Normal
4 (20.0%)
Euthanized
2 (10.0%)

Miconazole Nitrate + Chlorhexidine Gluconate + Trizedta Adverse Event Insights

20 reports name Miconazole Nitrate + Chlorhexidine Gluconate + Trizedta; 2 recorded a death outcome (10.0% of reported events, not a population-level mortality rate). Active ingredient: Miconazole Nitrate + Chlorhexidine Gluconate + Trizedta. Administration routes: Topical, Unknown, Cutaneous, Auricular (Otic).

By species: Dog (16 reports), Cat (4 reports). By breed: Domestic Shorthair (4), Retriever - Golden (2), Sheepdog - Shetland (2).

Leading clinical signs: Lethargy (see also Central nervous system depression in Neurological) (5), Vomiting (3), Neutropenia (3), Lack of efficacy - NOS (2). Outcome, 20 coded reports: Ongoing leads at 40.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.