Drug profile

The FDA adverse-event record for Methylprednisone

16 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Methylprednisone. See the species affected, top reactions, and outcomes below.

16
adverse-event reports
18.8%
death-coded share
Dog
most-reported species
3
Inappetence - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
16
Total Reports
3
Deaths Reported
18.8%
Death Rate

Active Ingredients

Methylprednisone

Administration Routes

UnknownOral

Species Affected

Dog 9
Cat 7

Most Affected Breeds

Domestic Shorthair 4
Bulldog 1
Domestic Longhair 1
Retriever - Golden 1
Maltese 1
Russian 1
Beagle 1
Terrier - Bull - American Pit 1
Crossbred Canine/dog 1
Cat (other) 1

Most Reported Reactions

Inappetence 3
Other abnormal test result NOS 2
Seizure NOS 2
Weight loss 2
Death by euthanasia 2
Lethargy (see also Central nervous system depression in 'Neurological') 2
Elevated total bilirubin 2
Not eating 2
Neurological symptoms NOS 1
Application site hair loss 1
Pain NOS 1
Lameness 1

Outcome Breakdown

Ongoing
8 (50.0%)
Recovered/Normal
3 (18.8%)
Outcome Unknown
2 (12.5%)
Euthanized
2 (12.5%)
Died
1 (6.3%)

Methylprednisone Adverse Event Insights

16 reports name Methylprednisone; 3 recorded a death outcome (18.8% of reported events, not a population-level mortality rate). Active ingredient: Methylprednisone. Administration routes: Unknown, Oral.

By species: Dog (9 reports), Cat (7 reports). By breed: Domestic Shorthair (4), Bulldog (1), Domestic Longhair (1).

Leading clinical signs: Inappetence (3), Other abnormal test result NOS (2), Seizure NOS (2), Weight loss (2). Outcome, 16 coded reports: Ongoing leads at 50.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.