Drug profile

The FDA adverse-event record for Methylprednisolone Acetate Injectable Suspension

19 FDA reports name Methylprednisolone Acetate Injectable Suspension, a lower-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#1855 of 2,679
by report volume (all drugs)
19
adverse-event reports
10.5%
death-coded share
Cat
most-reported species
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Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Methylprednisolone Acetate Injectable Suspension ranks #1827 of 2679 by total reports (19). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1827
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Methylprednisolone Acetate Injectable Suspension has 19 reports now versus 19 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Methylprednisolone Acetate Injectable Suspension changes

Signature read: 19 reports place Methylprednisolone Acetate Injectable Suspension in the lower third of FDA AER volume (#1855 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
19
Total Reports
2
Deaths Reported
10.5%
Death-coded share of reports

Active Ingredients

Methylprednisolone Acetate Injectable Suspension

Administration Routes

UnknownSubcutaneousIntramuscular

Species Affected

Cat 18
Dog 1

Most Affected Breeds

Domestic Shorthair 15
Domestic Mediumhair 2
Domestic Longhair 1
Retriever - Labrador 1

Most Reported Reactions

Inappetence 4
Lethargy (see also Central nervous system depression in 'Neurological') 4
Weight loss 3
Other abnormal test result NOS 3
Lack of efficacy - NOS 3
Vomiting 2
Behavioural disorder NOS 2
Pyoderma 2
INEFFECTIVE, ATOPY CONTROL 2
Hypersalivation 2
Neoplasia NOS 2
Death by euthanasia 2

Outcome Breakdown

Outcome Unknown
7 (36.8%)
Recovered/Normal
7 (36.8%)
Ongoing
3 (15.8%)
Euthanized
2 (10.5%)

Methylprednisolone Acetate Injectable Suspension: lower report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Methylprednisolone Acetate Injectable Suspension (#1855 of 2,679 by report volume); death-coded 10.5%. PlainBreed drug row · report volume stamp 19 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →