Drug profile

The FDA adverse-event record for Mepivacaine

14 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Mepivacaine. See the species affected, top reactions, and outcomes below.

14
adverse-event reports
21.4%
death-coded share
Cat
most-reported species
5
Uncoded sign - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
14
Total Reports
3
Deaths Reported
21.4%
Death Rate

Active Ingredients

Mepivacaine

Administration Routes

UnknownParenteralIntra-ArticularIntraocularOral

Species Affected

Cat 10
Horse 2
Dog 1
Cattle 1

Most Affected Breeds

Domestic Shorthair 6
Cat (unknown) 2
Crossbred Equine/horse 1
Dachshund (unspecified) 1
Domestic Longhair 1
Cattle (other) 1
Horse (other) 1
Domestic Mediumhair 1

Most Reported Reactions

Uncoded sign 5
Hiding 5
Dysphoria 4
Hyperactivity 3
Vocalisation 3
Dilated pupils 3
Not eating 3
Constipation 3
Increased heart rate 2
Elevated aspartate aminotransferase (AST) 2
Elevated temperature 2
Hypoalbuminaemia 2

Outcome Breakdown

Ongoing
5 (35.7%)
Recovered/Normal
4 (28.6%)
Died
2 (14.3%)
Outcome Unknown
2 (14.3%)
Euthanized
1 (7.1%)

Mepivacaine Adverse Event Insights

14 reports name Mepivacaine; 3 recorded a death outcome (21.4% of reported events, not a population-level mortality rate). Active ingredient: Mepivacaine. Administration routes: Unknown, Parenteral, Intra-Articular, Intraocular.

By species: Cat (10 reports), Horse (2 reports), Dog (1 reports). By breed: Domestic Shorthair (6), Cat (unknown) (2), Crossbred Equine/horse (1).

Leading clinical signs: Uncoded sign (5), Hiding (5), Dysphoria (4), Hyperactivity (3). Outcome, 14 coded reports: Ongoing leads at 35.7%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.