Drug profile

The FDA adverse-event record for Lotilaner,Moxidectin,Praziquantel,Pyrantel Pamoate

1,067 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Lotilaner,Moxidectin,Praziquantel,Pyrantel Pamoate. See the species affected, top reactions, and outcomes below.

1,067
adverse-event reports
2.6%
death-coded share
Dog
most-reported species
296
Vomiting - top reaction
Verify with FDA CVM →
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,067
Total Reports
28
Deaths Reported
2.6%
Death Rate

Active Ingredients

Lotilaner,Moxidectin,Praziquantel,Pyrantel Pamoate

Administration Routes

OralUnknownTopical

Species Affected

Dog 962
Unknown 104
Cat 1

Most Affected Breeds

Unknown 104
Retriever - Labrador 95
Retriever - Golden 84
Dog (unknown) 76
Shepherd Dog - Australian 52
Shih Tzu 40
Chihuahua 38
Crossbred Canine/dog 37
Shepherd Dog - German 36
Pit Bull 27

Most Reported Reactions

Vomiting 296
Diarrhoea 236
Lethargy (see also Central nervous system depression in Neurological) 118
UNPALATABLE 112
Behavioural disorder NOS 61
Emesis (multiple) 53
Lack of efficacy (endoparasite) - hookworm 49
Not eating 43
Other abnormal test result NOS 43
Lack of efficacy (ectoparasite) - flea 43
Seizure NOS 38
Product defect, product difficult to use/handle (see also 'Drug device difficult to use/handle') 36

Outcome Breakdown

Recovered/Normal
394 (40.9%)
Outcome Unknown
331 (34.3%)
Ongoing
211 (21.9%)
Died
20 (2.1%)
Euthanized
8 (0.8%)

Lotilaner,Moxidectin,Praziquantel,Pyrantel Pamoate Adverse Event Insights

1,067 reports name Lotilaner,Moxidectin,Praziquantel,Pyrantel Pamoate; 28 recorded a death outcome (2.6% of reported events, not a population-level mortality rate). Active ingredient: Lotilaner,Moxidectin,Praziquantel,Pyrantel Pamoate. Administration routes: Oral, Unknown, Topical.

By species: Dog (962 reports), Unknown (104 reports), Cat (1 reports). By breed: Unknown (104), Retriever - Labrador (95), Retriever - Golden (84).

Leading clinical signs: Vomiting (296), Diarrhoea (236), Lethargy (see also Central nervous system depression in Neurological) (118), UNPALATABLE (112). Outcome, 964 coded reports: Recovered/Normal leads at 40.9%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.