Drug profile

The FDA adverse-event record for Loratidine

155 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Loratidine. See the species affected, top reactions, and outcomes below.

155
adverse-event reports
5.2%
death-coded share
Dog
most-reported species
26
Emesis - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
155
Total Reports
8
Deaths Reported
5.2%
Death Rate

Active Ingredients

Loratidine

Administration Routes

OralUnknown

Species Affected

Dog 142
Human 7
Cat 4
Unknown 1
Monkey 1

Most Affected Breeds

Retriever - Labrador 24
Unknown 9
Shih Tzu 7
Retriever - Golden 7
Crossbred Canine/dog 5
Terrier - Yorkshire 5
Bulldog 5
Terrier - Bull - American Pit 5
Domestic Shorthair 4
Maltese 4

Most Reported Reactions

Emesis 26
Lethargy (see also Central nervous system depression in 'Neurological') 19
Lack of efficacy - NOS 19
Vomiting 15
Diarrhoea 12
Other abnormal test result NOS 10
INEFFECTIVE, ATOPY CONTROL 10
Behavioural disorder NOS 8
Seizure NOS 7
Anorexia 6
Lack of efficacy (ectoparasite) - flea 6
Pruritus 6

Outcome Breakdown

Ongoing
59 (38.3%)
Recovered/Normal
49 (31.8%)
Outcome Unknown
27 (17.5%)
Recovered with Sequela
11 (7.1%)
Euthanized
5 (3.2%)
Died
3 (1.9%)

Loratidine Adverse Event Insights

155 reports name Loratidine; 8 recorded a death outcome (5.2% of reported events, not a population-level mortality rate). Active ingredient: Loratidine. Administration routes: Oral, Unknown.

By species: Dog (142 reports), Human (7 reports), Cat (4 reports). By breed: Retriever - Labrador (24), Unknown (9), Shih Tzu (7).

Leading clinical signs: Emesis (26), Lethargy (see also Central nervous system depression in 'Neurological') (19), Lack of efficacy - NOS (19), Vomiting (15). Outcome, 154 coded reports: Ongoing leads at 38.3%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.