Drug profile

The FDA adverse-event record for Lokivetmab

180 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Lokivetmab. See the species affected, top reactions, and outcomes below.

180
adverse-event reports
5.6%
death-coded share
Dog
most-reported species
26
Lack of efficacy - NOS - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
180
Total Reports
10
Deaths Reported
5.6%
Death Rate

Active Ingredients

Lokivetmab

Administration Routes

UnknownSubcutaneousParenteralOralSubconjunctival

Species Affected

Dog 180

Most Affected Breeds

Retriever - Labrador 17
Shih Tzu 11
Terrier - Yorkshire 9
American Pit Bull Terrier 9
Chihuahua 8
Maltese 8
Pit Bull 7
Beagle 6
Bulldog - French 6
Shepherd Dog - German 5

Most Reported Reactions

Lack of efficacy - NOS 26
Vomiting 19
Decreased appetite 16
Lethargy (see also Central nervous system depression in Neurological) 15
Elevated serum alkaline phosphatase (SAP) 13
Diarrhoea 13
Elevated alanine aminotransferase (ALT) 11
Lethargy (see also Central nervous system depression in 'Neurological') 11
Pain NOS 9
Inappropriate urination 9
Abnormal adrenocorticotropic hormone (ACTH) stimulation test 9
Proteinuria 8

Outcome Breakdown

Outcome Unknown
97 (53.6%)
Recovered/Normal
44 (24.3%)
Ongoing
25 (13.8%)
Euthanized
8 (4.4%)
Recovered with Sequela
5 (2.8%)
Died
2 (1.1%)

Lokivetmab Adverse Event Insights

180 reports name Lokivetmab; 10 recorded a death outcome (5.6% of reported events, not a population-level mortality rate). Active ingredient: Lokivetmab. Administration routes: Unknown, Subcutaneous, Parenteral, Oral.

By species: Dog (180 reports). By breed: Retriever - Labrador (17), Shih Tzu (11), Terrier - Yorkshire (9).

Leading clinical signs: Lack of efficacy - NOS (26), Vomiting (19), Decreased appetite (16), Lethargy (see also Central nervous system depression in Neurological) (15). Outcome, 181 coded reports: Outcome Unknown leads at 53.6%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.