Drug profile

The FDA adverse-event record for Lidocaine Hcl

83 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Lidocaine Hcl. See the species affected, top reactions, and outcomes below.

83
adverse-event reports
25.3%
death-coded share
Dog
most-reported species
16
Lethargy (see also Central nervous system depression in 'Neurological') - top reaction
Verify with FDA CVM →
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
83
Total Reports
21
Deaths Reported
25.3%
Death Rate

Active Ingredients

Lidocaine Hcl

Administration Routes

UnknownOtherIntravenousSubcutaneousTopicalIntradermalIntra-ArticularParenteral

Species Affected

Dog 41
Cat 20
Cattle 16
Horse 5
Rabbit 1

Most Affected Breeds

Holstein-Friesian also known as Holstein 14
Domestic Shorthair 10
Retriever - Labrador 3
Siamese 3
Domestic Mediumhair 3
Retriever - Golden 3
Dachshund (unspecified) 2
Spaniel (unspecified) 2
Great Pyrenees 2
Cat (unknown) 2

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 16
Other abnormal test result NOS 11
Anorexia 11
Death by euthanasia 11
Vomiting 9
Death 9
Injection site swelling 9
Emesis 6
Cardiac arrest 6
Ataxia 6
Pale mucous membrane 5
Anaemia NOS 4

Outcome Breakdown

Recovered/Normal
26 (31.3%)
Ongoing
25 (30.1%)
Euthanized
11 (13.3%)
Died
10 (12.0%)
Recovered with Sequela
6 (7.2%)
Outcome Unknown
5 (6.0%)

Lidocaine Hcl Adverse Event Insights

83 reports name Lidocaine Hcl; 21 recorded a death outcome (25.3% of reported events, not a population-level mortality rate). Active ingredient: Lidocaine Hcl. Administration routes: Unknown, Other, Intravenous, Subcutaneous.

By species: Dog (41 reports), Cat (20 reports), Cattle (16 reports). By breed: Holstein-Friesian also known as Holstein (14), Domestic Shorthair (10), Retriever - Labrador (3).

Leading clinical signs: Lethargy (see also Central nervous system depression in 'Neurological') (16), Other abnormal test result NOS (11), Anorexia (11), Death by euthanasia (11). Outcome, 83 coded reports: Recovered/Normal leads at 31.3%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.