Drug profile

The FDA adverse-event record for Lidocaine Hcl

83 FDA reports name Lidocaine Hcl, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#861 of 2,679
by report volume (all drugs)
83
adverse-event reports
25.3%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Lidocaine Hcl ranks #860 of 2679 by total reports (83) and #164 of 1130 by death-coded share (25.3%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#860
This drug, reports of 2679
#164
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Lidocaine Hcl has 83 reports now versus 83 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Lidocaine Hcl changes

Signature read: Lidocaine Hcl's 25.3% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
83
Total Reports
21
Deaths Reported
25.3%
Death-coded share of reports

Active Ingredients

Lidocaine Hcl

Administration Routes

UnknownOtherIntravenousSubcutaneousTopicalIntradermalIntra-ArticularParenteral

Species Affected

Dog 41
Cat 20
Cattle 16
Horse 5
Rabbit 1

Most Affected Breeds

Holstein-Friesian also known as Holstein 14
Domestic Shorthair 10
Retriever - Labrador 3
Siamese 3
Domestic Mediumhair 3
Retriever - Golden 3
Dachshund (unspecified) 2
Spaniel (unspecified) 2
Great Pyrenees 2
Cat (unknown) 2

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 16
Other abnormal test result NOS 11
Anorexia 11
Death by euthanasia 11
Vomiting 9
Death 9
Injection site swelling 9
Emesis 6
Cardiac arrest 6
Ataxia 6
Pale mucous membrane 5
Anaemia NOS 4

Outcome Breakdown

Recovered/Normal
26 (31.3%)
Ongoing
25 (30.1%)
Euthanized
11 (13.3%)
Died
10 (12.0%)
Recovered with Sequela
6 (7.2%)
Outcome Unknown
5 (6.0%)

Lidocaine Hcl: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Lidocaine Hcl, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Lidocaine Hcl (#861 of 2,679 by report volume); death-coded 25.3%. PlainBreed drug row · death-coded share stamp 25.3% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →