Drug profile

The FDA adverse-event record for Leptospira Canicola,Sc1503,Killed + Leptospira Grippotyphosa,Sc4397,Killed + Leptospira Icterohaemorrhagiae,Sc1518,Killed + Leptospira Pomona,T262,Killed

170 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Leptospira Canicola,Sc1503,Killed + Leptospira Grippotyphosa,Sc4397,Killed + Leptospira Icterohaemorrhagiae,Sc1518,Killed + Leptospira Pomona,T262,Killed. See the species affected, top reactions, and outcomes below.

170
adverse-event reports
9.4%
death-coded share
Dog
most-reported species
53
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
170
Total Reports
16
Deaths Reported
9.4%
Death Rate

Active Ingredients

Leptospira Canicola,Sc1503,KilledLeptospira Grippotyphosa,Sc4397,KilledLeptospira Icterohaemorrhagiae,Sc1518,KilledLeptospira Pomona,T262,Killed

Administration Routes

SubcutaneousUnknown

Species Affected

Dog 170

Most Affected Breeds

Retriever - Labrador 13
Maltese 11
Crossbred Canine/dog 9
Retriever - Golden 8
Pit Bull 7
Terrier - Yorkshire 7
Spaniel - King Charles Cavalier 7
Shepherd Dog - Australian 7
Chihuahua 6
Shepherd Dog - German 5

Most Reported Reactions

Vomiting 53
Lethargy (see also Central nervous system depression in 'Neurological') 37
Diarrhoea 23
Injection site swelling 15
Other abnormal test result NOS 15
Lethargy (see also Central nervous system depression in Neurological) 14
Anorexia 13
Injection site pain 12
Fever 12
Not eating 10
Injection site lump 9
Lameness 9

Outcome Breakdown

Recovered/Normal
67 (39.2%)
Outcome Unknown
63 (36.8%)
Ongoing
24 (14.0%)
Died
10 (5.8%)
Euthanized
7 (4.1%)

Leptospira Canicola,Sc1503,Killed + Leptospira Grippotyphosa,Sc4397,Killed + Leptospira Icterohaemorrhagiae,Sc1518,Killed + Leptospira Pomona,T262,Killed Adverse Event Insights

170 reports name Leptospira Canicola,Sc1503,Killed + Leptospira Grippotyphosa,Sc4397,Killed + Leptospira Icterohaemorrhagiae,Sc1518,Killed + Leptospira Pomona,T262,Killed; 16 recorded a death outcome (9.4% of reported events, not a population-level mortality rate). Active ingredients: Leptospira Canicola,Sc1503,Killed, Leptospira Grippotyphosa,Sc4397,Killed, Leptospira Icterohaemorrhagiae,Sc1518,Killed, Leptospira Pomona,T262,Killed. Administration routes: Subcutaneous, Unknown.

By species: Dog (170 reports). By breed: Retriever - Labrador (13), Maltese (11), Crossbred Canine/dog (9).

Leading clinical signs: Vomiting (53), Lethargy (see also Central nervous system depression in 'Neurological') (37), Diarrhoea (23), Injection site swelling (15). Outcome, 171 coded reports: Recovered/Normal leads at 39.2%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.