Drug profile

The FDA adverse-event record for Leptospira Canicola,Sc1503,Killed + Leptospira Grippotyphosa,Sc4397,Killed + Leptospira Icterohaemorrhagiae,Sc1518,Killed + Leptospira Pomona,T262,Killed

176 FDA reports name Leptospira Canicola,Sc1503,Killed + Leptospira Grippotyphosa,Sc4397,Killed + Leptospira Icterohaemorrhagiae,Sc1518,Killed + Leptospira Pomona,T262,Killed, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#570 of 2,679
by report volume (all drugs)
176
adverse-event reports
9.1%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Leptospira Canicola,Sc1503,Killed + Leptospira Grippotyphosa,Sc4397,Killed + Leptospira Icterohaemorrhagiae,Sc1518,Killed + Leptospira Pomona,T262,Killed ranks #570 of 2679 by total reports (176) and #590 of 1130 by death-coded share (9.1%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#570
This drug, reports of 2679
#590
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Leptospira Canicola,Sc1503,Killed + Leptospira Grippotyphosa,Sc4397,Killed + Leptospira Icterohaemorrhagiae,Sc1518,Killed + Leptospira Pomona,T262,Killed has 176 reports now versus 172 in that prior snapshot: 4 more (2.3%).

Report change
+4
Death-coded reports
+0
Death-coded share
−0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Leptospira Canicola,Sc1503,Killed + Leptospira Grippotyphosa,Sc4397,Killed + Leptospira Icterohaemorrhagiae,Sc1518,Killed + Leptospira Pomona,T262,Killed changes

Signature read: 176 reports place Leptospira Canicola,Sc1503,Killed + Leptospira Grippotyphosa,Sc4397,Killed + Leptospira Icterohaemorrhagiae,Sc1518,Killed + Leptospira Pomona,T262,Killed in the upper third of FDA AER volume (#570 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
176
Total Reports
16
Deaths Reported
9.1%
Death-coded share of reports

Active Ingredients

Leptospira Canicola,Sc1503,KilledLeptospira Grippotyphosa,Sc4397,KilledLeptospira Icterohaemorrhagiae,Sc1518,KilledLeptospira Pomona,T262,Killed

Administration Routes

SubcutaneousUnknown

Species Affected

Dog 176

Most Affected Breeds

Maltese 13
Retriever - Labrador 13
Crossbred Canine/dog 9
Retriever - Golden 8
Chihuahua 8
Pit Bull 7
Terrier - Yorkshire 7
Spaniel - King Charles Cavalier 7
Shepherd Dog - Australian 7
Shepherd Dog - German 5

Most Reported Reactions

Vomiting 53
Lethargy (see also Central nervous system depression in 'Neurological') 37
Diarrhoea 23
Lethargy (see also Central nervous system depression in Neurological) 18
Injection site swelling 15
Other abnormal test result NOS 15
Injection site pain 13
Anorexia 13
Fever 12
Not eating 11
Seizure NOS 10
Injection site lump 9

Outcome Breakdown

Recovered/Normal
69 (39.0%)
Outcome Unknown
66 (37.3%)
Ongoing
25 (14.1%)
Died
10 (5.6%)
Euthanized
7 (4.0%)

Leptospira Canicola,Sc1503,Killed + Leptospira Grippotyphosa,Sc4397,Killed + Leptospira Icterohaemorrhagiae,Sc1518,Killed + Leptospira Pomona,T262,Killed: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Leptospira Canicola,Sc1503,Killed + Leptospira Grippotyphosa,Sc4397,Killed + Leptospira Icterohaemorrhagiae,Sc1518,Killed + Leptospira Pomona,T262,Killed, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (9.1% here), distinct from the volume row.

Amoxicillin/Clavulanate 9.1% Capstar 9.1% Feline Leukemia Vaccine, Killed Virus 9.1% Kaolin + Pectin + Enterococcus Faecium 9.1%

What to do with this drug

  • Compare Leptospira Canicola,Sc1503,Killed + Leptospira Grippotyphosa,Sc4397,Killed + Leptospira Icterohaemorrhagiae,Sc1518,Killed + Leptospira Pomona,T262,Killed's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Leptospira Canicola,Sc1503,Killed + Leptospira Grippotyphosa,Sc4397,Killed + Leptospira Icterohaemorrhagiae,Sc1518,Killed + Leptospira Pomona,T262,Killed (#570 of 2,679 by report volume); death-coded 9.1%. PlainBreed drug row · report volume stamp 176 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →