Drug profile

The FDA adverse-event record for Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str

3,015 FDA reports name Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#74 of 2,679
by report volume (all drugs)
3,015
adverse-event reports
10.2%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str ranks #74 of 2679 by total reports (3,015) and #536 of 1130 by death-coded share (10.2%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#74
This drug, reports of 2679
#536
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str has 3,015 reports now versus 2,972 in that prior snapshot: 43 more (1.4%).

Report change
+43
Death-coded reports
+6
Death-coded share
+0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str changes

Signature read: death-coded report count at 308 is the most distinctive stamp on Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
3,015
Total Reports
308
Deaths Reported
10.2%
Death-coded share of reports

Active Ingredients

Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str

Administration Routes

SubcutaneousIntramuscularUnknownSubconjunctivalNasalOral

Species Affected

Dog 2,980
Cattle 33
Cat 2

Most Affected Breeds

Retriever - Labrador 296
Terrier - Bull - American Pit 237
Chihuahua 142
Retriever - Golden 126
Crossbred Canine/dog 110
Terrier - Yorkshire 102
Shih Tzu 99
Boxer (German Boxer) 97
Shepherd Dog - Australian 86
Dachshund (unspecified) 83

Most Reported Reactions

Vomiting 1,313
Lethargy (see also Central nervous system depression in 'Neurological') 565
Facial swelling (see also 'Skin') 492
Anaphylaxis 431
Diarrhoea 387
Hives (see also 'Skin') 382
Pale mucous membrane 242
Lethargy (see also Central nervous system depression in Neurological) 236
Fever 235
Not eating 170
Anorexia 168
Death 153

Outcome Breakdown

Ongoing
1,506 (49.8%)
Recovered/Normal
1,030 (34.0%)
Outcome Unknown
181 (6.0%)
Died
163 (5.4%)
Euthanized
145 (4.8%)
Recovered with Sequela
1 (0.0%)

Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (10.2% here), distinct from the volume row.

Chlorhexidine 10.2% Borrelia Burgdorferi Strain Ips 930-34-081596; Borrelia Burgdorferi Strain B-31 10.2% Pyrantel 10.2% Corona Vaccine 10.1%

What to do with this drug

  • Compare Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str (#74 of 2,679 by report volume); death-coded 10.2%. PlainBreed drug row · death-coded report count stamp 308 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →