Drug profile

The FDA adverse-event record for Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str

2,917 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str. See the species affected, top reactions, and outcomes below.

2,917
adverse-event reports
10.1%
death-coded share
Dog
most-reported species
1,285
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
2,917
Total Reports
294
Deaths Reported
10.1%
Death Rate

Active Ingredients

Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str

Administration Routes

SubcutaneousIntramuscularUnknownSubconjunctivalNasalOral

Species Affected

Dog 2,883
Cattle 32
Cat 2

Most Affected Breeds

Retriever - Labrador 285
Terrier - Bull - American Pit 232
Chihuahua 139
Retriever - Golden 121
Crossbred Canine/dog 101
Terrier - Yorkshire 99
Shih Tzu 97
Boxer (German Boxer) 96
Shepherd Dog - Australian 84
Dachshund (unspecified) 79

Most Reported Reactions

Vomiting 1,285
Lethargy (see also Central nervous system depression in 'Neurological') 565
Facial swelling (see also 'Skin') 492
Anaphylaxis 422
Hives (see also 'Skin') 382
Diarrhoea 369
Pale mucous membrane 230
Fever 227
Lethargy (see also Central nervous system depression in Neurological) 202
Anorexia 162
Not eating 156
Death 148

Outcome Breakdown

Ongoing
1,455 (49.7%)
Recovered/Normal
1,003 (34.3%)
Outcome Unknown
175 (6.0%)
Died
159 (5.4%)
Euthanized
135 (4.6%)
Recovered with Sequela
1 (0.0%)

Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str Adverse Event Insights

2,917 reports name Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str; 294 recorded a death outcome (10.1% of reported events, not a population-level mortality rate). Active ingredient: Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str. Administration routes: Subcutaneous, Intramuscular, Unknown, Subconjunctival.

By species: Dog (2,883 reports), Cattle (32 reports), Cat (2 reports). By breed: Retriever - Labrador (285), Terrier - Bull - American Pit (232), Chihuahua (139).

Leading clinical signs: Vomiting (1,285), Lethargy (see also Central nervous system depression in 'Neurological') (565), Facial swelling (see also 'Skin') (492), Anaphylaxis (422). Outcome, 2,928 coded reports: Ongoing leads at 49.7%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.