Drug profile

The FDA adverse-event record for Leptospira Canicola L-15 Strain C-51; Leptospira Grippotyphosa 1550 Lot 10005 St

616 FDA reports name Leptospira Canicola L-15 Strain C-51; Leptospira Grippotyphosa 1550 Lot 10005 St, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#264 of 2,679
by report volume (all drugs)
616
adverse-event reports
12.5%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Leptospira Canicola L-15 Strain C-51; Leptospira Grippotyphosa 1550 Lot 10005 St ranks #264 of 2679 by total reports (616) and #441 of 1130 by death-coded share (12.5%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#264
This drug, reports of 2679
#441
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Leptospira Canicola L-15 Strain C-51; Leptospira Grippotyphosa 1550 Lot 10005 St has 616 reports now versus 616 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Leptospira Canicola L-15 Strain C-51; Leptospira Grippotyphosa 1550 Lot 10005 St changes

Signature read: death-coded report count at 77 is the most distinctive stamp on Leptospira Canicola L-15 Strain C-51; Leptospira Grippotyphosa 1550 Lot 10005 St's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
616
Total Reports
77
Deaths Reported
12.5%
Death-coded share of reports

Active Ingredients

Leptospira Canicola L-15 Strain C-51; Leptospira Grippotyphosa 1550 Lot 10005 St

Administration Routes

SubcutaneousUnknown

Species Affected

Dog 615
Cattle 1

Most Affected Breeds

Retriever - Labrador 59
Terrier - Bull - American Pit 43
Chihuahua 28
Boxer (German Boxer) 26
Retriever - Golden 25
Terrier - Yorkshire 24
Beagle 20
Shih Tzu 20
Maltese 18
Dachshund (unspecified) 17

Most Reported Reactions

Vomiting 222
Lethargy (see also Central nervous system depression in 'Neurological') 165
Facial swelling (see also 'Skin') 104
Anorexia 86
Anaphylactoid reaction 77
Other abnormal test result NOS 75
Diarrhoea 70
Pale mucous membrane 55
Hives (see also 'Skin') 55
Urticaria 54
Fever 52
Elevated alanine aminotransferase (ALT) 52

Outcome Breakdown

Ongoing
283 (45.9%)
Recovered/Normal
233 (37.8%)
Euthanized
40 (6.5%)
Died
37 (6.0%)
Outcome Unknown
23 (3.7%)

Leptospira Canicola L-15 Strain C-51; Leptospira Grippotyphosa 1550 Lot 10005 St: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Leptospira Canicola L-15 Strain C-51; Leptospira Grippotyphosa 1550 Lot 10005 St, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (12.5% here), distinct from the volume row.

Activated Charcoal 12.5% Da2Ppv+L*4 (Orig S-P Us) Lv+Kb 12.5% Diethylstilbestrol (Des) 12.5% Proviable 12.5%

What to do with this drug

  • Compare Leptospira Canicola L-15 Strain C-51; Leptospira Grippotyphosa 1550 Lot 10005 St's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Leptospira Canicola L-15 Strain C-51; Leptospira Grippotyphosa 1550 Lot 10005 St (#264 of 2,679 by report volume); death-coded 12.5%. PlainBreed drug row · death-coded report count stamp 77 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →