Drug profile

The FDA adverse-event record for Leptospira Canicola L-15 Strain C-51; Leptospira Grippotyphosa 1550 Lot 10005 St

616 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Leptospira Canicola L-15 Strain C-51; Leptospira Grippotyphosa 1550 Lot 10005 St. See the species affected, top reactions, and outcomes below.

616
adverse-event reports
12.5%
death-coded share
Dog
most-reported species
222
Vomiting - top reaction
Verify with FDA CVM →
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
616
Total Reports
77
Deaths Reported
12.5%
Death Rate

Active Ingredients

Leptospira Canicola L-15 Strain C-51; Leptospira Grippotyphosa 1550 Lot 10005 St

Administration Routes

SubcutaneousUnknown

Species Affected

Dog 615
Cattle 1

Most Affected Breeds

Retriever - Labrador 59
Terrier - Bull - American Pit 43
Chihuahua 28
Boxer (German Boxer) 26
Retriever - Golden 25
Terrier - Yorkshire 24
Beagle 20
Shih Tzu 20
Maltese 18
Dachshund (unspecified) 17

Most Reported Reactions

Vomiting 222
Lethargy (see also Central nervous system depression in 'Neurological') 165
Facial swelling (see also 'Skin') 104
Anorexia 86
Anaphylactoid reaction 77
Other abnormal test result NOS 75
Diarrhoea 70
Pale mucous membrane 55
Hives (see also 'Skin') 55
Urticaria 54
Fever 52
Elevated alanine aminotransferase (ALT) 52

Outcome Breakdown

Ongoing
283 (45.9%)
Recovered/Normal
233 (37.8%)
Euthanized
40 (6.5%)
Died
37 (6.0%)
Outcome Unknown
23 (3.7%)

Leptospira Canicola L-15 Strain C-51; Leptospira Grippotyphosa 1550 Lot 10005 St Adverse Event Insights

616 reports name Leptospira Canicola L-15 Strain C-51; Leptospira Grippotyphosa 1550 Lot 10005 St; 77 recorded a death outcome (12.5% of reported events, not a population-level mortality rate). Active ingredient: Leptospira Canicola L-15 Strain C-51; Leptospira Grippotyphosa 1550 Lot 10005 St. Administration routes: Subcutaneous, Unknown.

By species: Dog (615 reports), Cattle (1 reports). By breed: Retriever - Labrador (59), Terrier - Bull - American Pit (43), Chihuahua (28).

Leading clinical signs: Vomiting (222), Lethargy (see also Central nervous system depression in 'Neurological') (165), Facial swelling (see also 'Skin') (104), Anorexia (86). Outcome, 616 coded reports: Ongoing leads at 45.9%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.