Drug profile

The FDA adverse-event record for Leptospira Canicola, Hond Urecht Strain,Leptospira Grippotyphosa, F4397 Strain,Leptospira Icterohaemorrhagiae, Copenhageni Strain,Leptospira Pomona, Kennewicki Strain

83 FDA reports name Leptospira Canicola, Hond Urecht Strain,Leptospira Grippotyphosa, F4397 Strain,Leptospira Icterohaemorrhagiae, Copenhageni Strain,Leptospira Pomona, Kennewicki Strain, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#860 of 2,679
by report volume (all drugs)
83
adverse-event reports
13.3%
death-coded share
Dog
most-reported species
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Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Leptospira Canicola, Hond Urecht Strain,Leptospira Grippotyphosa, F4397 Strain,Leptospira Icterohaemorrhagiae, Copenhageni Strain,Leptospira Pomona, Kennewicki Strain ranks #860 of 2679 by total reports (83) and #418 of 1130 by death-coded share (13.3%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#860
This drug, reports of 2679
#418
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Leptospira Canicola, Hond Urecht Strain,Leptospira Grippotyphosa, F4397 Strain,Leptospira Icterohaemorrhagiae, Copenhageni Strain,Leptospira Pomona, Kennewicki Strain has 83 reports now versus 71 in that prior snapshot: 12 more (16.9%).

Report change
+12
Death-coded reports
+1
Death-coded share
−0.8 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Leptospira Canicola, Hond Urecht Strain,Leptospira Grippotyphosa, F4397 Strain,Leptospira Icterohaemorrhagiae, Copenhageni Strain,Leptospira Pomona, Kennewicki Strain changes

Signature read: death-coded report count at 11 is the most distinctive stamp on Leptospira Canicola, Hond Urecht Strain,Leptospira Grippotyphosa, F4397 Strain,Leptospira Icterohaemorrhagiae, Copenhageni Strain,Leptospira Pomona, Kennewicki Strain's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
83
Total Reports
11
Deaths Reported
13.3%
Death-coded share of reports

Active Ingredients

Leptospira Canicola, Hond Urecht Strain,Leptospira Grippotyphosa, F4397 Strain,Leptospira Icterohaemorrhagiae, Copenhageni Strain,Leptospira Pomona, Kennewicki Strain

Administration Routes

SubcutaneousUnknownParenteral

Species Affected

Dog 81
Unknown 2

Most Affected Breeds

Retriever - Golden 9
Retriever - Labrador 9
Maltese 7
Boxer (German Boxer) 5
Crossbred Canine/dog 5
Shepherd Dog - German 4
Shepherd Dog - Australian 4
Pinscher - Miniature 3
Shih Tzu 3
Pug 3

Most Reported Reactions

Lethargy (see also Central nervous system depression in Neurological) 19
Vomiting 17
Elevated serum alkaline phosphatase (ALP) 14
Lack of efficacy (bacteria) - Leptospira 11
Injection site lump 10
Other abnormal test result NOS 10
Elevated alanine aminotransferase (ALT) 9
Not eating 9
Diarrhoea 9
Death by euthanasia 8
Injection site swelling 8
Cough 7

Outcome Breakdown

Outcome Unknown
28 (34.6%)
Recovered/Normal
26 (32.1%)
Ongoing
16 (19.8%)
Euthanized
8 (9.9%)
Died
3 (3.7%)

Leptospira Canicola, Hond Urecht Strain,Leptospira Grippotyphosa, F4397 Strain,Leptospira Icterohaemorrhagiae, Copenhageni Strain,Leptospira Pomona, Kennewicki Strain: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Leptospira Canicola, Hond Urecht Strain,Leptospira Grippotyphosa, F4397 Strain,Leptospira Icterohaemorrhagiae, Copenhageni Strain,Leptospira Pomona, Kennewicki Strain, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (13.3% here), distinct from the volume row.

Dasuquin 13.2% Glucosamine Supplement 13.3% Sedative (Unknown) 13.3% Gentamicin, Mometasone Furoate, And Clotrimazole 13.1%

What to do with this drug

  • Compare Leptospira Canicola, Hond Urecht Strain,Leptospira Grippotyphosa, F4397 Strain,Leptospira Icterohaemorrhagiae, Copenhageni Strain,Leptospira Pomona, Kennewicki Strain's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Leptospira Canicola, Hond Urecht Strain,Leptospira Grippotyphosa, F4397 Strain,Leptospira Icterohaemorrhagiae, Copenhageni Strain,Leptospira Pomona, Kennewicki Strain (#860 of 2,679 by report volume); death-coded 13.3%. PlainBreed drug row · death-coded report count stamp 11 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →