Drug profile

The FDA adverse-event record for Keppra

179 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Keppra. See the species affected, top reactions, and outcomes below.

179
adverse-event reports
27.9%
death-coded share
Dog
most-reported species
98
Seizure NOS - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
179
Total Reports
50
Deaths Reported
27.9%
Death Rate

Active Ingredients

Keppra

Administration Routes

UnknownOralIntravenous

Species Affected

Dog 173
Cat 6

Most Affected Breeds

Retriever - Labrador 16
Crossbred Canine/dog 9
Shepherd Dog - German 9
Retriever - Golden 9
Chihuahua 8
Terrier - Bull - American Pit 8
Siberian Husky 7
Terrier - Yorkshire 6
Shih Tzu 6
Beagle 5

Most Reported Reactions

Seizure NOS 98
Death by euthanasia 34
Diarrhoea 18
Ataxia 16
Lethargy (see also Central nervous system depression in Neurological) 16
Death 15
Elevated alanine aminotransferase (ALT) 13
Vomiting 12
Not eating 11
Limb weakness 11
Behavioural disorder NOS 11
Urinary tract infection 11

Outcome Breakdown

Ongoing
97 (54.2%)
Euthanized
34 (19.0%)
Outcome Unknown
16 (8.9%)
Recovered/Normal
16 (8.9%)
Died
16 (8.9%)

Keppra Adverse Event Insights

179 reports name Keppra; 50 recorded a death outcome (27.9% of reported events, not a population-level mortality rate). Active ingredient: Keppra. Administration routes: Unknown, Oral, Intravenous.

By species: Dog (173 reports), Cat (6 reports). By breed: Retriever - Labrador (16), Crossbred Canine/dog (9), Shepherd Dog - German (9).

Leading clinical signs: Seizure NOS (98), Death by euthanasia (34), Diarrhoea (18), Ataxia (16). Outcome, 179 coded reports: Ongoing leads at 54.2%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.