Drug profile

The FDA adverse-event record for Joint Supplement

331 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Joint Supplement. See the species affected, top reactions, and outcomes below.

331
adverse-event reports
17.8%
death-coded share
Dog
most-reported species
54
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
331
Total Reports
59
Deaths Reported
17.8%
Death Rate

Active Ingredients

Joint Supplement

Administration Routes

OralUnknownParenteral

Species Affected

Dog 317
Cat 13
Other 1

Most Affected Breeds

Retriever - Labrador 41
Crossbred Canine/dog 25
Retriever - Golden 20
Shepherd Dog - German 16
Terrier - Bull - American Pit 15
Chihuahua 11
Shepherd Dog - Australian 10
Collie - Border 8
Domestic Shorthair 8
Terrier - Yorkshire 7

Most Reported Reactions

Vomiting 54
Death by euthanasia 44
Lethargy (see also Central nervous system depression in Neurological) 44
Diarrhoea 40
Lack of efficacy - NOS 26
Polyuria 25
Urinary tract infection 25
Decreased appetite 25
Anorexia 22
Elevated alanine aminotransferase (ALT) 22
Not eating 22
Elevated serum alkaline phosphatase (ALP) 22

Outcome Breakdown

Ongoing
141 (42.6%)
Outcome Unknown
72 (21.8%)
Recovered/Normal
59 (17.8%)
Euthanized
44 (13.3%)
Died
15 (4.5%)

Joint Supplement Adverse Event Insights

331 reports name Joint Supplement; 59 recorded a death outcome (17.8% of reported events, not a population-level mortality rate). Active ingredient: Joint Supplement. Administration routes: Oral, Unknown, Parenteral.

By species: Dog (317 reports), Cat (13 reports), Other (1 reports). By breed: Retriever - Labrador (41), Crossbred Canine/dog (25), Retriever - Golden (20).

Leading clinical signs: Vomiting (54), Death by euthanasia (44), Lethargy (see also Central nervous system depression in Neurological) (44), Diarrhoea (40). Outcome, 331 coded reports: Ongoing leads at 42.6%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.