Drug profile

Here's what the FDA CVM extract says about Ivermectin 136Mcg, Pyrantel Pamoate 114Mg, Praziquantel 114Mg

The CVM extract lists 950 reports for Ivermectin 136Mcg, Pyrantel Pamoate 114Mg, Praziquantel 114Mg, a high-volume entry. Species, reactions, and outcomes are below.

#191 of 2,679
by report volume (all drugs)
950
adverse-event reports
1.4%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Ivermectin 136Mcg, Pyrantel Pamoate 114Mg, Praziquantel 114Mg ranks #191 of 2679 by total reports (950) and #1041 of 1130 by death-coded share (1.4%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#191
This drug, reports of 2679
#1041
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Ivermectin 136Mcg, Pyrantel Pamoate 114Mg, Praziquantel 114Mg has 950 reports now versus 950 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Ivermectin 136Mcg, Pyrantel Pamoate 114Mg, Praziquantel 114Mg changes

Signature read: 950 reports place Ivermectin 136Mcg, Pyrantel Pamoate 114Mg, Praziquantel 114Mg in the upper third of FDA AER volume (#191 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
950
Total Reports
13
Deaths Reported
1.4%
Death-coded share of reports

Active Ingredients

Ivermectin 136Mcg, Pyrantel Pamoate 114Mg, Praziquantel 114Mg

Administration Routes

OralUnknown

Species Affected

Dog 917
Unknown 30
Cat 2
Human 1

Most Affected Breeds

Crossbred Canine/dog 134
Beagle 91
Retriever - Labrador 73
Collie - Border 34
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 31
Dog (unknown) 31
Unknown 31
Spaniel - Cocker American 31
Mixed (Dog) 28
Shepherd Dog - German 27

Most Reported Reactions

Vomiting 327
INEFFECTIVE, HEARTWORM LARVAE 243
Lack of efficacy - NOS 174
Lack of efficacy (endoparasite) - hookworm 122
Diarrhoea 102
Lethargy (see also Central nervous system depression in 'Neurological') 83
INEFFECTIVE, ASCARIDS NOS 75
Lack of efficacy (endoparasite) - tapeworm 40
Drug dose administration interval too long 36
Overdose 29
Underdose 21
Underfilling, Package 20

Outcome Breakdown

Outcome Unknown
494 (53.6%)
Recovered/Normal
389 (42.2%)
Ongoing
15 (1.6%)
Recovered with Sequela
10 (1.1%)
Died
8 (0.9%)
Euthanized
5 (0.5%)

Ivermectin 136Mcg, Pyrantel Pamoate 114Mg, Praziquantel 114Mg: low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Ivermectin 136Mcg, Pyrantel Pamoate 114Mg, Praziquantel 114Mg, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

  • Compare Ivermectin 136Mcg, Pyrantel Pamoate 114Mg, Praziquantel 114Mg's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Death-coded share and mortality rate measure different things -- see the distinction explained. Understanding adverse events
  • See how this report count compares across the full drug directory. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Ivermectin 136Mcg, Pyrantel Pamoate 114Mg, Praziquantel 114Mg (#191 of 2,679 by report volume); death-coded 1.4%. PlainBreed drug row · report volume stamp 950 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →