Drug profile

The FDA adverse-event record for Ivermectin 136Mcg, Pyrantel Pamoate 114Mg

74 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Ivermectin 136Mcg, Pyrantel Pamoate 114Mg. See the species affected, top reactions, and outcomes below.

74
adverse-event reports
0.0%
death-coded share
Dog
most-reported species
48
INEFFECTIVE, HEARTWORM LARVAE - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
74
Total Reports
0
Deaths Reported
0.0%
Death Rate

Active Ingredients

Ivermectin 136Mcg, Pyrantel Pamoate 114Mg

Administration Routes

OralUnknown

Species Affected

Dog 69
Unknown 5

Most Affected Breeds

Retriever - Labrador 11
Shepherd Dog - German 6
Beagle 6
Spaniel - Cocker American 5
Unknown 5
Crossbred Canine/dog 5
Boxer (German Boxer) 4
Siberian Husky 3
Mixed (Dog) 3
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 2

Most Reported Reactions

INEFFECTIVE, HEARTWORM LARVAE 48
Vomiting 13
Lack of efficacy - NOS 11
Drug dose omission 5
Diarrhoea 4
Underdose 4
Underfilling, Package 4
Lethargy (see also Central nervous system depression in 'Neurological') 3
Abnormal radiograph finding 3
Not eating 2
Behavioural disorder NOS 2
Uncoded sign 2

Outcome Breakdown

Outcome Unknown
41 (59.4%)
Recovered/Normal
22 (31.9%)
Recovered with Sequela
5 (7.2%)
Ongoing
1 (1.4%)

Ivermectin 136Mcg, Pyrantel Pamoate 114Mg Adverse Event Insights

74 reports name Ivermectin 136Mcg, Pyrantel Pamoate 114Mg; 0 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). Active ingredient: Ivermectin 136Mcg, Pyrantel Pamoate 114Mg. Administration routes: Oral, Unknown.

By species: Dog (69 reports), Unknown (5 reports). By breed: Retriever - Labrador (11), Shepherd Dog - German (6), Beagle (6).

Leading clinical signs: INEFFECTIVE, HEARTWORM LARVAE (48), Vomiting (13), Lack of efficacy - NOS (11), Drug dose omission (5). Outcome, 69 coded reports: Outcome Unknown leads at 59.4%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.