Drug profile

The FDA adverse-event record for Ivermectin 0.5% Pour-On Topical Solution

347 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Ivermectin 0.5% Pour-On Topical Solution. See the species affected, top reactions, and outcomes below.

347
adverse-event reports
3.5%
death-coded share
Cattle
most-reported species
179
Systemic disorder NOS - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
347
Total Reports
12
Deaths Reported
3.5%
Death Rate

Active Ingredients

Ivermectin 0.5% Pour-On Topical Solution

Administration Routes

TopicalOtherUnknownOralSubcutaneousTransdermal

Species Affected

Cattle 286
Unknown 38
Dog 10
Human 7
Cat 2
Goat 2
Sheep 1
Rabbit 1

Most Affected Breeds

Aberdeen Angus 121
Cattle (unknown) 59
Unknown 49
Crossbred Bovine/Cattle 46
Cattle (other) 35
Charolais 8
Simmental 5
Hereford cattle 3
Dog (unknown) 2
European 2

Most Reported Reactions

Systemic disorder NOS 179
Lack of efficacy (ectoparasite) - lice 145
Hair loss NOS 111
Scratching 85
Rubbing 66
INEFFECTIVE, LICE BITING 61
Pruritus 33
Itching 29
General hair loss 26
SKIN SCRAPING ABNORMAL 26
Rubra 23
Lack of efficacy (ectoparasite) - NOS 21

Outcome Breakdown

Outcome Unknown
217 (69.6%)
Recovered with Sequela
48 (15.4%)
Ongoing
23 (7.4%)
Recovered/Normal
12 (3.8%)
Died
11 (3.5%)
Euthanized
1 (0.3%)

Ivermectin 0.5% Pour-On Topical Solution Adverse Event Insights

347 reports name Ivermectin 0.5% Pour-On Topical Solution; 12 recorded a death outcome (3.5% of reported events, not a population-level mortality rate). Active ingredient: Ivermectin 0.5% Pour-On Topical Solution. Administration routes: Topical, Other, Unknown, Oral.

By species: Cattle (286 reports), Unknown (38 reports), Dog (10 reports). By breed: Aberdeen Angus (121), Cattle (unknown) (59), Unknown (49).

Leading clinical signs: Systemic disorder NOS (179), Lack of efficacy (ectoparasite) - lice (145), Hair loss NOS (111), Scratching (85). Outcome, 312 coded reports: Outcome Unknown leads at 69.6%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.