Drug profile

The FDA adverse-event record for Isoflupredone Acetate; Neomycin Sulfate; Tetracaine Hydrochloride

78 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Isoflupredone Acetate; Neomycin Sulfate; Tetracaine Hydrochloride. See the species affected, top reactions, and outcomes below.

78
adverse-event reports
11.5%
death-coded share
Dog
most-reported species
17
Polydipsia - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
78
Total Reports
9
Deaths Reported
11.5%
Death Rate

Active Ingredients

Isoflupredone Acetate; Neomycin Sulfate; Tetracaine Hydrochloride

Administration Routes

TopicalUnknownOralAuricular (Otic)Ophthalmic

Species Affected

Dog 53
Unknown 16
Cat 6
Human 3

Most Affected Breeds

Unknown 19
Shih Tzu 5
Retriever - Labrador 4
Retriever - Golden 4
Pug 4
Domestic Shorthair 4
Terrier (unspecified) 3
Chihuahua 3
Mixed (Dog) 2
Shepherd Dog - German 2

Most Reported Reactions

Polydipsia 17
Polyuria 14
Other abnormal test result NOS 11
Lethargy (see also Central nervous system depression in 'Neurological') 9
Diarrhoea 7
Leucocytosis NOS 5
Urinary incontinence 5
Anorexia 5
Vomiting 5
Lack of efficacy - NOS 5
Tubes, Leaking 4
Seal, Abnormal 4

Outcome Breakdown

Ongoing
34 (54.8%)
Recovered/Normal
11 (17.7%)
Outcome Unknown
8 (12.9%)
Died
5 (8.1%)
Euthanized
4 (6.5%)

Isoflupredone Acetate; Neomycin Sulfate; Tetracaine Hydrochloride Adverse Event Insights

78 reports name Isoflupredone Acetate; Neomycin Sulfate; Tetracaine Hydrochloride; 9 recorded a death outcome (11.5% of reported events, not a population-level mortality rate). Active ingredient: Isoflupredone Acetate; Neomycin Sulfate; Tetracaine Hydrochloride. Administration routes: Topical, Unknown, Oral, Auricular (Otic).

By species: Dog (53 reports), Unknown (16 reports), Cat (6 reports). By breed: Unknown (19), Shih Tzu (5), Retriever - Labrador (4).

Leading clinical signs: Polydipsia (17), Polyuria (14), Other abnormal test result NOS (11), Lethargy (see also Central nervous system depression in 'Neurological') (9). Outcome, 62 coded reports: Ongoing leads at 54.8%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.