Drug profile

The FDA adverse-event record for Interceptor Plus

179 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Interceptor Plus. See the species affected, top reactions, and outcomes below.

179
adverse-event reports
4.5%
death-coded share
Dog
most-reported species
76
Lack of efficacy (endoparasite) - heartworm - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
179
Total Reports
8
Deaths Reported
4.5%
Death Rate

Active Ingredients

Interceptor Plus

Administration Routes

OralUnknownSubcutaneous

Species Affected

Dog 179

Most Affected Breeds

Retriever - Labrador 26
Crossbred Canine/dog 22
Retriever - Golden 14
Shepherd Dog - Australian 8
Boxer (German Boxer) 8
Shepherd Dog - German 8
Dog (unknown) 6
Terrier - Yorkshire 6
Shih Tzu 5
Siberian Husky 5

Most Reported Reactions

Lack of efficacy (endoparasite) - heartworm 76
Vomiting 26
Seizure NOS 21
Diarrhoea 17
Emesis (multiple) 5
Lethargy (see also Central nervous system depression in 'Neurological') 5
Decreased appetite 5
Mental impairment NOS 5
Ataxia 5
Panting 5
Tremor 5
Walking difficulty 5

Outcome Breakdown

Ongoing
103 (57.5%)
Outcome Unknown
38 (21.2%)
Recovered/Normal
30 (16.8%)
Died
5 (2.8%)
Euthanized
3 (1.7%)

Interceptor Plus Adverse Event Insights

179 reports name Interceptor Plus; 8 recorded a death outcome (4.5% of reported events, not a population-level mortality rate). Active ingredient: Interceptor Plus. Administration routes: Oral, Unknown, Subcutaneous.

By species: Dog (179 reports). By breed: Retriever - Labrador (26), Crossbred Canine/dog (22), Retriever - Golden (14).

Leading clinical signs: Lack of efficacy (endoparasite) - heartworm (76), Vomiting (26), Seizure NOS (21), Diarrhoea (17). Outcome, 179 coded reports: Ongoing leads at 57.5%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.