Infectious Bovine Rhinotracheitis Virus(Ts), Rlb 106;Bovine Parainfluenza Virus

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456 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
456
Total Reports
414
Deaths Reported
9080.0%
Death Rate

Active Ingredients

Infectious Bovine Rhinotracheitis Virus(Ts), Rlb 106;Bovine Parainfluenza Virus

Administration Routes

NasalSubcutaneousUnknownOralIntramuscular

Species Affected

Cattle 454
Unknown 1
Dog 1

Most Affected Breeds

Mixed (Cattle) 361
Aberdeen Angus 27
Holstein-Friesian also known as Holstein 24
Cattle (other) 19
Crossbred Bovine/Cattle 5
Red Angus 3
Jersey 3
Devon - South 2
Cattle (unknown) 2
Hereford cattle 2

Most Reported Reactions

Death 369
Lack of efficacy - NOS 300
Lack of efficacy (bacteria) - NOS 47
Necropsy performed 46
INEFFECTIVE, ANTIBIOTIC 30
Lack of efficacy (mycoplasma) - NOS 21
Unrelated death 19
CULTURE/TITER DATA ABNORMAL 15
Lack of efficacy (bacteria) - Mannheimia haemolytica 14
Anaphylaxis 12
Anaphylactic-type reaction 11
Death by euthanasia 11

Outcome Breakdown

Died
406 (50.5%)
Outcome Unknown
258 (32.1%)
Recovered/Normal
58 (7.2%)
Ongoing
51 (6.3%)
Euthanized
16 (2.0%)
Recovered with Sequela
15 (1.9%)

Data Summary

Metric Value
Total adverse event reports 456
Reports involving death 414
Case-fatality rate (reported events) 9080.0%
Distinct species in reports 3
Distinct breeds in reports 17
Distinct reactions reported 20
Active ingredients on file 1

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER). Counts reflect voluntary reports only.

Infectious Bovine Rhinotracheitis Virus(Ts), Rlb 106;Bovine Parainfluenza Virus Adverse Event Insights

The FDA Center for Veterinary Medicine database currently holds 456 adverse event reports referencing Infectious Bovine Rhinotracheitis Virus(Ts), Rlb 106;Bovine Parainfluenza Virus, including 414 reports in which the animal died — a 9080.0% case-fatality figure among reported events only, not a population-level mortality rate. Active ingredient on file: Infectious Bovine Rhinotracheitis Virus(Ts), Rlb 106;Bovine Parainfluenza Virus. Reported administration routes include Nasal, Subcutaneous, Unknown, Oral. These numbers reflect voluntary submissions from pet owners, veterinarians, and manufacturers and therefore under-represent mild events and over-represent severe ones — a pattern the FDA has documented repeatedly for pharmacovigilance datasets.

The species most frequently named in Infectious Bovine Rhinotracheitis Virus(Ts), Rlb 106;Bovine Parainfluenza Virus reports are Cattle (454 reports), Unknown (1 reports), Dog (1 reports), with Cattle accounting for the largest share. Within those species, Mixed (Cattle) (361), Aberdeen Angus (27), Holstein-Friesian also known as Holstein (24) appear most often — though breed popularity and ownership density shape these counts as much as any drug-specific sensitivity. This distribution matters because the same active ingredient can behave very differently across body sizes, ages, and species physiology.

The most commonly reported clinical signs associated with Infectious Bovine Rhinotracheitis Virus(Ts), Rlb 106;Bovine Parainfluenza Virus are Death (369), Lack of efficacy - NOS (300), Lack of efficacy (bacteria) - NOS (47), Necropsy performed (46). Of the 804 reports with a coded outcome, Died is the leading category at 50.5%. Because FDA adverse event data describes correlation rather than causation, these figures are best used to frame informed questions with a veterinarian and to compare reporting patterns across related products — not as a standalone safety verdict on Infectious Bovine Rhinotracheitis Virus(Ts), Rlb 106;Bovine Parainfluenza Virus.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial