Drug profile

The FDA adverse-event record for Infectious Bovine Rhinotracheitis Virus(Ts), Rlb 106;Bovine Parainfluenza Virus

456 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Infectious Bovine Rhinotracheitis Virus(Ts), Rlb 106;Bovine Parainfluenza Virus. See the species affected, top reactions, and outcomes below.

456
adverse-event reports
90.8%
death-coded share
Cattle
most-reported species
369
Death - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
456
Total Reports
414
Deaths Reported
90.8%
Death Rate

Active Ingredients

Infectious Bovine Rhinotracheitis Virus(Ts), Rlb 106;Bovine Parainfluenza Virus

Administration Routes

NasalSubcutaneousUnknownOralIntramuscular

Species Affected

Cattle 454
Unknown 1
Dog 1

Most Affected Breeds

Mixed (Cattle) 361
Aberdeen Angus 27
Holstein-Friesian also known as Holstein 24
Cattle (other) 19
Crossbred Bovine/Cattle 5
Red Angus 3
Jersey 3
Devon - South 2
Cattle (unknown) 2
Hereford cattle 2

Most Reported Reactions

Death 369
Lack of efficacy - NOS 300
Lack of efficacy (bacteria) - NOS 47
Necropsy performed 46
INEFFECTIVE, ANTIBIOTIC 30
Lack of efficacy (mycoplasma) - NOS 21
Unrelated death 19
CULTURE/TITER DATA ABNORMAL 15
Lack of efficacy (bacteria) - Mannheimia haemolytica 14
Anaphylaxis 12
Anaphylactic-type reaction 11
Death by euthanasia 11

Outcome Breakdown

Died
406 (50.5%)
Outcome Unknown
258 (32.1%)
Recovered/Normal
58 (7.2%)
Ongoing
51 (6.3%)
Euthanized
16 (2.0%)
Recovered with Sequela
15 (1.9%)

Infectious Bovine Rhinotracheitis Virus(Ts), Rlb 106;Bovine Parainfluenza Virus Adverse Event Insights

456 reports name Infectious Bovine Rhinotracheitis Virus(Ts), Rlb 106;Bovine Parainfluenza Virus; 414 recorded a death outcome (90.8% of reported events, not a population-level mortality rate). Active ingredient: Infectious Bovine Rhinotracheitis Virus(Ts), Rlb 106;Bovine Parainfluenza Virus. Administration routes: Nasal, Subcutaneous, Unknown, Oral.

By species: Cattle (454 reports), Unknown (1 reports), Dog (1 reports). By breed: Mixed (Cattle) (361), Aberdeen Angus (27), Holstein-Friesian also known as Holstein (24).

Leading clinical signs: Death (369), Lack of efficacy - NOS (300), Lack of efficacy (bacteria) - NOS (47), Necropsy performed (46). Outcome, 804 coded reports: Died leads at 50.5%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.