Drug profile

The FDA adverse-event record for Indoxacarb

50 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Indoxacarb. Species, reactions, and outcomes follow.

#1123 of 2,679
by report volume (all drugs)
50
adverse-event reports
2.0%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Indoxacarb ranks #1120 of 2679 by total reports (50) and #987 of 1130 by death-coded share (2.0%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1120
This drug, reports of 2679
#987
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Indoxacarb has 50 reports now versus 50 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Indoxacarb changes

Signature read: Indoxacarb's 2.0% death-coded share is among the lowest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
50
Total Reports
1
Deaths Reported
2.0%
Death-coded share of reports

Active Ingredients

Indoxacarb

Administration Routes

TopicalUnknownOralCutaneous

Species Affected

Dog 36
Cat 14

Most Affected Breeds

Domestic Shorthair 10
Domestic Mediumhair 3
Retriever - Golden 3
Shepherd Dog - German 3
Dog (other) 3
Chihuahua 2
Retriever - Labrador 2
Terrier - Rat 2
Terrier - Bull - American Pit 2
Cat (unknown) 1

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 10
Emesis 8
Anorexia 5
Lack of efficacy - NOS 5
Vomiting 5
Lack of efficacy (ectoparasite) - flea 4
Other abnormal test result NOS 4
INEFFECTIVE, HEARTWORM LARVAE 4
Ataxia 3
Anaemia NOS 3
Gagging 2
UNPALATABLE 2

Outcome Breakdown

Outcome Unknown
25 (50.0%)
Recovered/Normal
15 (30.0%)
Ongoing
9 (18.0%)
Euthanized
1 (2.0%)

Indoxacarb: low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Nationwide drugs with similar profiles

Two openFDA-derived peer sets for Indoxacarb, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Indoxacarb (#1123 of 2,679 by report volume); death-coded 2.0%. PlainBreed drug row · death-coded share stamp 2.0% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →