Drug profile

The FDA adverse-event record for Incurin

149 FDA reports name Incurin, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#632 of 2,679
by report volume (all drugs)
149
adverse-event reports
18.1%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Incurin ranks #632 of 2679 by total reports (149) and #274 of 1130 by death-coded share (18.1%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#632
This drug, reports of 2679
#274
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Incurin has 149 reports now versus 146 in that prior snapshot: 3 more (2.1%).

Report change
+3
Death-coded reports
+0
Death-coded share
−0.4 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Incurin changes

Signature read: death-coded report count at 27 is the most distinctive stamp on Incurin's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
149
Total Reports
27
Deaths Reported
18.1%
Death-coded share of reports

Active Ingredients

Incurin

Administration Routes

OralUnknownSubcutaneous

Species Affected

Dog 149

Most Affected Breeds

Retriever - Labrador 32
Crossbred Canine/dog 17
Shepherd Dog - Australian 6
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 5
Terrier - Bull - American Pit 5
Collie - Border 5
Shepherd Dog - German 5
Saint Bernard Dog 4
Doberman Pinscher 4
Shepherd (unspecified) 4

Most Reported Reactions

Polydipsia 29
Polyuria 24
Urinary incontinence 18
Lack of efficacy - NOS 17
Death by euthanasia 16
Ataxia 16
Limb weakness 16
Lethargy (see also Central nervous system depression in Neurological) 16
Vomiting 13
Panting 12
Not eating 11
Diarrhoea 11

Outcome Breakdown

Ongoing
97 (65.1%)
Euthanized
16 (10.7%)
Recovered/Normal
14 (9.4%)
Outcome Unknown
11 (7.4%)
Died
11 (7.4%)

Incurin: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Incurin, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (18.1% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Incurin (#632 of 2,679 by report volume); death-coded 18.1%. PlainBreed drug row · death-coded report count stamp 27 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →