Drug profile

The FDA adverse-event record for Imrab 3 Tf - 1905.23

259 FDA reports name Imrab 3 Tf - 1905.23, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#463 of 2,679
by report volume (all drugs)
259
adverse-event reports
8.5%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Imrab 3 Tf - 1905.23 ranks #462 of 2679 by total reports (259) and #620 of 1130 by death-coded share (8.5%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#462
This drug, reports of 2679
#620
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Imrab 3 Tf - 1905.23 has 259 reports now versus 259 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Imrab 3 Tf - 1905.23 changes

Signature read: 259 reports place Imrab 3 Tf - 1905.23 in the upper third of FDA AER volume (#463 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
259
Total Reports
22
Deaths Reported
8.5%
Death-coded share of reports

Active Ingredients

Imrab 3 Tf - 1905.23

Administration Routes

SubcutaneousUnknownIntramuscular

Species Affected

Dog 251
Cat 8

Most Affected Breeds

Retriever - Labrador 20
Crossbred Canine/dog 19
Chihuahua 17
Retriever - Golden 16
Terrier - Yorkshire 11
Shih Tzu 11
Shepherd Dog - German 10
Boxer (German Boxer) 9
Terrier (unspecified) 9
Dachshund (unspecified) 8

Most Reported Reactions

Vomiting 90
Lethargy (see also Central nervous system depression in 'Neurological') 60
Diarrhoea 57
Other abnormal test result NOS 42
Anorexia 26
Injection site lump 17
Pruritus 17
Not eating 17
Death 13
Seizure NOS 13
Behavioural disorder NOS 12
Injection site swelling 12

Outcome Breakdown

Outcome Unknown
130 (49.8%)
Recovered/Normal
90 (34.5%)
Ongoing
18 (6.9%)
Died
13 (5.0%)
Euthanized
9 (3.4%)
Recovered with Sequela
1 (0.4%)

Imrab 3 Tf - 1905.23: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Imrab 3 Tf - 1905.23, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (259 here).

Similar death-coded share

Nearest other drugs by death-coded share (8.5% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Imrab 3 Tf - 1905.23 (#463 of 2,679 by report volume); death-coded 8.5%. PlainBreed drug row · report volume stamp 259 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →