Drug profile

The FDA adverse-event record for Imidacloprid/Pyriproxyfen

23 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Imidacloprid/Pyriproxyfen. See the species affected, top reactions, and outcomes below.

23
adverse-event reports
0.0%
death-coded share
Cat
most-reported species
16
Lack of efficacy (ectoparasite) - flea - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
23
Total Reports
0
Deaths Reported
0.0%
Death Rate

Active Ingredients

Imidacloprid/Pyriproxyfen

Administration Routes

Topical

Species Affected

Cat 20
Dog 3

Most Affected Breeds

Domestic Shorthair 10
Domestic Longhair 3
Cat (unknown) 3
Domestic Mediumhair 2
Norwegian Forest 1
Doberman Pinscher 1
Sheepdog - Shetland 1
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 1
Mixed (Cat) 1

Most Reported Reactions

Lack of efficacy (ectoparasite) - flea 16
Pruritus 5
Drug administration error 5
Expired drug administered 5
Scratching 4
Incorrect dose administered NOS 4
Skin disorders NOS 3
Hyperexcitation 3
Excessive chewing, licking and/or grooming 3
Hyperactivity 2
Panting 2
Foaming at the mouth 2

Outcome Breakdown

Outcome Unknown
14 (60.9%)
Recovered/Normal
5 (21.7%)
Ongoing
4 (17.4%)

Imidacloprid/Pyriproxyfen Adverse Event Insights

23 reports name Imidacloprid/Pyriproxyfen; 0 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). Active ingredient: Imidacloprid/Pyriproxyfen. Administration route: Topical.

By species: Cat (20 reports), Dog (3 reports). By breed: Domestic Shorthair (10), Domestic Longhair (3), Cat (unknown) (3).

Leading clinical signs: Lack of efficacy (ectoparasite) - flea (16), Pruritus (5), Drug administration error (5), Expired drug administered (5). Outcome, 23 coded reports: Outcome Unknown leads at 60.9%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.