Drug profile

The FDA adverse-event record for Imidacloprid+Moxidectin

21 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Imidacloprid+Moxidectin. See the species affected, top reactions, and outcomes below.

21
adverse-event reports
28.6%
death-coded share
Dog
most-reported species
8
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
21
Total Reports
6
Deaths Reported
28.6%
Death Rate

Active Ingredients

Imidacloprid+Moxidectin

Administration Routes

TopicalOralUnknown

Species Affected

Dog 11
Cat 10

Most Affected Breeds

Domestic Shorthair 8
Shih Tzu 4
Dog (unknown) 2
Crossbred Canine/dog 1
Cat (unknown) 1
Havanese 1
Schnauzer - Miniature 1
Retriever - Labrador 1
Greyhound 1
Domestic Mediumhair 1

Most Reported Reactions

Vomiting 8
Hypersalivation 7
Nausea 7
Anorexia 7
Lethargy (see also Central nervous system depression in Neurological) 7
Defect Unknown/Not Specified 7
Found dead 6
Lack of efficacy (ectoparasite) - flea 3
Overdose 2
Itching 2
Licking 2
Head shake - behavioural disorder 2

Outcome Breakdown

Outcome Unknown
9 (42.9%)
Died
6 (28.6%)
Recovered/Normal
4 (19.0%)
Ongoing
2 (9.5%)

Imidacloprid+Moxidectin Adverse Event Insights

21 reports name Imidacloprid+Moxidectin; 6 recorded a death outcome (28.6% of reported events, not a population-level mortality rate). Active ingredient: Imidacloprid+Moxidectin. Administration routes: Topical, Oral, Unknown.

By species: Dog (11 reports), Cat (10 reports). By breed: Domestic Shorthair (8), Shih Tzu (4), Dog (unknown) (2).

Leading clinical signs: Vomiting (8), Hypersalivation (7), Nausea (7), Anorexia (7). Outcome, 21 coded reports: Outcome Unknown leads at 42.9%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.