Imidacloprid + Permethrin + Pyriproxyfen
545 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
545
Total Reports
23
Deaths Reported
420.0%
Death Rate
Active Ingredients
ImidaclopridImidacloprid + Permethrin + PyriproxyfenPermethrinPyriproxyfen
Administration Routes
TopicalUnknownOralOther
Species Affected
Dog 529
Cat 15
Unknown 1
Most Affected Breeds
Retriever - Labrador 37
Dog (unknown) 31
Chihuahua 29
Crossbred Canine/dog 27
Shih Tzu 26
Maltese 23
Retriever - Golden 21
Pit Bull 21
Terrier - Yorkshire 18
Shepherd Dog - German 18
Most Reported Reactions
Lack of efficacy (ectoparasite) - flea 134
Pruritus 92
Vomiting 65
Lethargy (see also Central nervous system depression in 'Neurological') 61
Behavioural disorder NOS 56
Diarrhoea 37
Other abnormal test result NOS 37
Application site pruritus 34
Anorexia 29
Agitation 27
Seizure NOS 23
Ataxia 22
Outcome Breakdown
Outcome Unknown
277 (50.8%)
Recovered/Normal
146 (26.8%)
Ongoing
97 (17.8%)
Euthanized
13 (2.4%)
Died
10 (1.8%)
Recovered with Sequela
2 (0.4%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.