Drug profile

The FDA adverse-event record for Imidacloprid, Permethrin And Pyriproxyfen

20 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Imidacloprid, Permethrin And Pyriproxyfen. See the species affected, top reactions, and outcomes below.

20
adverse-event reports
10.0%
death-coded share
Dog
most-reported species
5
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
20
Total Reports
2
Deaths Reported
10.0%
Death Rate

Active Ingredients

Imidacloprid, Permethrin And Pyriproxyfen

Administration Routes

TopicalUnknownOral

Species Affected

Dog 19
Cat 1

Most Affected Breeds

Chihuahua 2
Maltese 2
Terrier - Boston 2
Retriever - Labrador 2
Berger de Brie (Briard) - Briard 1
Terrier - Irish 1
Shepherd Dog - Australian 1
Weimaraner 1
Collie - Border 1
Corgi (unspecified) 1

Most Reported Reactions

Vomiting 5
Other abnormal test result NOS 5
Bloody diarrhoea 5
Seizure NOS 4
Palpable mass NOS 4
Lethargy (see also Central nervous system depression in 'Neurological') 3
Anorexia 3
Fever 2
Restlessness 2
Histiocytoma 2
Dermal mass 2
PR-SKIN, LESION(S) 2

Outcome Breakdown

Ongoing
7 (35.0%)
Outcome Unknown
6 (30.0%)
Recovered/Normal
5 (25.0%)
Euthanized
1 (5.0%)
Died
1 (5.0%)

Imidacloprid, Permethrin And Pyriproxyfen Adverse Event Insights

20 reports name Imidacloprid, Permethrin And Pyriproxyfen; 2 recorded a death outcome (10.0% of reported events, not a population-level mortality rate). Active ingredient: Imidacloprid, Permethrin And Pyriproxyfen. Administration routes: Topical, Unknown, Oral.

By species: Dog (19 reports), Cat (1 reports). By breed: Chihuahua (2), Maltese (2), Terrier - Boston (2).

Leading clinical signs: Vomiting (5), Other abnormal test result NOS (5), Bloody diarrhoea (5), Seizure NOS (4). Outcome, 20 coded reports: Ongoing leads at 35.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.