Drug profile

The FDA adverse-event record for Imidacloprid, Permethrin And Pyriproxyfen

20 FDA reports name Imidacloprid, Permethrin And Pyriproxyfen, a lower-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#1801 of 2,679
by report volume (all drugs)
20
adverse-event reports
10.0%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Imidacloprid, Permethrin And Pyriproxyfen ranks #1778 of 2679 by total reports (20). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1778
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Imidacloprid, Permethrin And Pyriproxyfen has 20 reports now versus 20 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Imidacloprid, Permethrin And Pyriproxyfen changes

Signature read: report volume at 20 is the most distinctive stamp on Imidacloprid, Permethrin And Pyriproxyfen's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
20
Total Reports
2
Deaths Reported
10.0%
Death-coded share of reports

Active Ingredients

Imidacloprid, Permethrin And Pyriproxyfen

Administration Routes

TopicalUnknownOral

Species Affected

Dog 19
Cat 1

Most Affected Breeds

Chihuahua 2
Maltese 2
Terrier - Boston 2
Retriever - Labrador 2
Berger de Brie (Briard) - Briard 1
Terrier - Irish 1
Shepherd Dog - Australian 1
Weimaraner 1
Collie - Border 1
Corgi (unspecified) 1

Most Reported Reactions

Vomiting 5
Bloody diarrhoea 5
Other abnormal test result NOS 5
Seizure NOS 4
Palpable mass NOS 4
Lethargy (see also Central nervous system depression in 'Neurological') 3
Anorexia 3
Fever 2
Histiocytoma 2
Dermal mass 2
PR-SKIN, LESION(S) 2
Skin and/or appendage neoplasm NOS 2

Outcome Breakdown

Ongoing
7 (35.0%)
Outcome Unknown
6 (30.0%)
Recovered/Normal
5 (25.0%)
Euthanized
1 (5.0%)
Died
1 (5.0%)

Imidacloprid, Permethrin And Pyriproxyfen: lower report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Imidacloprid, Permethrin And Pyriproxyfen (#1801 of 2,679 by report volume); death-coded 10.0%. PlainBreed drug row · report volume stamp 20 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →