Drug profile

The FDA adverse-event record for Imidacloprid, Permethrin

31 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Imidacloprid, Permethrin. See the species affected, top reactions, and outcomes below.

31
adverse-event reports
12.9%
death-coded share
Dog
most-reported species
14
Lack of efficacy (ectoparasite) - flea - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
31
Total Reports
4
Deaths Reported
12.9%
Death Rate

Active Ingredients

Imidacloprid, Permethrin

Administration Routes

TopicalUnknownOral

Species Affected

Dog 31

Most Affected Breeds

Dog (unknown) 6
Retriever - Golden 3
Siberian Husky 3
Spaniel - Cocker American 2
Chihuahua 2
Beagle 2
Terrier - Yorkshire 2
Pekingese 1
Spitz - German Pomeranian 1
Pointing Dog - German Short-haired 1

Most Reported Reactions

Lack of efficacy (ectoparasite) - flea 14
Scratching 3
Death 3
Dermal cyst(s) 2
Ataxia 2
Febrile 2
Diarrhoea 2
Emesis (multiple) 2
Other abnormal test result NOS 2
Falling 2
Rash 1
Death by euthanasia 1

Outcome Breakdown

Outcome Unknown
18 (58.1%)
Recovered/Normal
5 (16.1%)
Ongoing
4 (12.9%)
Died
3 (9.7%)
Euthanized
1 (3.2%)

Imidacloprid, Permethrin Adverse Event Insights

31 reports name Imidacloprid, Permethrin; 4 recorded a death outcome (12.9% of reported events, not a population-level mortality rate). Active ingredient: Imidacloprid, Permethrin. Administration routes: Topical, Unknown, Oral.

By species: Dog (31 reports). By breed: Dog (unknown) (6), Retriever - Golden (3), Siberian Husky (3).

Leading clinical signs: Lack of efficacy (ectoparasite) - flea (14), Scratching (3), Death (3), Dermal cyst(s) (2). Outcome, 31 coded reports: Outcome Unknown leads at 58.1%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.