Drug profile

The FDA adverse-event record for Imidacloprid, Permethrin

31 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Imidacloprid, Permethrin. Species, reactions, and outcomes follow.

#1427 of 2,679
by report volume (all drugs)
31
adverse-event reports
12.9%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Imidacloprid, Permethrin ranks #1412 of 2679 by total reports (31). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1412
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Imidacloprid, Permethrin has 31 reports now versus 31 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Imidacloprid, Permethrin changes

Signature read: death-coded share at 12.9% is the most distinctive stamp on Imidacloprid, Permethrin's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
31
Total Reports
4
Deaths Reported
12.9%
Death-coded share of reports

Active Ingredients

Imidacloprid, Permethrin

Administration Routes

TopicalUnknownOral

Species Affected

Dog 31

Most Affected Breeds

Dog (unknown) 6
Retriever - Golden 3
Siberian Husky 3
Spaniel - Cocker American 2
Chihuahua 2
Beagle 2
Terrier - Yorkshire 2
Pekingese 1
Shepherd (unspecified) 1
Pointing Dog - German Short-haired 1

Most Reported Reactions

Lack of efficacy (ectoparasite) - flea 14
Scratching 3
Death 3
Ataxia 2
Febrile 2
Dermal cyst(s) 2
Diarrhoea 2
Other abnormal test result NOS 2
Emesis (multiple) 2
Falling 2
Rash 1
Death by euthanasia 1

Outcome Breakdown

Outcome Unknown
18 (58.1%)
Recovered/Normal
5 (16.1%)
Ongoing
4 (12.9%)
Died
3 (9.7%)
Euthanized
1 (3.2%)

Imidacloprid, Permethrin Adverse Event Insights

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Imidacloprid, Permethrin (#1427 of 2,679 by report volume); death-coded 12.9%. PlainBreed drug row · death-coded share stamp 12.9% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →