Drug profile

The FDA adverse-event record for Imidacloprid & Permethrin

46 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Imidacloprid & Permethrin. See the species affected, top reactions, and outcomes below.

46
adverse-event reports
10.9%
death-coded share
Dog
most-reported species
13
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
46
Total Reports
5
Deaths Reported
10.9%
Death Rate

Active Ingredients

Imidacloprid & Permethrin

Administration Routes

TopicalUnknownOther

Species Affected

Dog 45
Cat 1

Most Affected Breeds

Retriever - Labrador 6
Terrier - Bull - American Pit 4
Siberian Husky 3
Boxer (German Boxer) 3
Rottweiler 2
Spitz - German Pomeranian 2
Terrier (unspecified) 2
Beagle 2
Terrier - Yorkshire 2
Chihuahua 1

Most Reported Reactions

Vomiting 13
Seizure NOS 7
Lethargy (see also Central nervous system depression in 'Neurological') 7
Other abnormal test result NOS 5
INEFFECTIVE, ATOPY CONTROL 5
Anorexia 4
Behavioural disorder NOS 4
Death 3
Elevated serum alkaline phosphatase (SAP) 3
Lack of efficacy (ectoparasite) - flea 3
Ataxia 3
Panting 3

Outcome Breakdown

Ongoing
24 (52.2%)
Recovered/Normal
11 (23.9%)
Outcome Unknown
6 (13.0%)
Died
3 (6.5%)
Euthanized
2 (4.3%)

Imidacloprid & Permethrin Adverse Event Insights

46 reports name Imidacloprid & Permethrin; 5 recorded a death outcome (10.9% of reported events, not a population-level mortality rate). Active ingredient: Imidacloprid & Permethrin. Administration routes: Topical, Unknown, Other.

By species: Dog (45 reports), Cat (1 reports). By breed: Retriever - Labrador (6), Terrier - Bull - American Pit (4), Siberian Husky (3).

Leading clinical signs: Vomiting (13), Seizure NOS (7), Lethargy (see also Central nervous system depression in 'Neurological') (7), Other abnormal test result NOS (5). Outcome, 46 coded reports: Ongoing leads at 52.2%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.